CTSB, cathepsin B, 1508

N. diseases: 304; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.230 AlteredExpression disease BEFREE SerpinB3 (SB3) is a hypoxia and hypoxia-inducible factor (HIF)-2α-dependent cysteine-protease inhibitor up-regulated in hepatocellular carcinoma (HCC), released by cancer cells and able to stimulate proliferation and epithelial-to-mesenchymal-transition. 31817100 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.230 Biomarker disease BEFREE Integrin αvβ3 is required for cathepsin B-induced hepatocellular carcinoma progression. 25572981 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.230 GeneticVariation disease BEFREE The association between CTSB C76G SNP and greater tumor size may warrant further study in regards to the biology of HCC. 25106406 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.230 Biomarker disease RGD Effect of vitamin E and human placenta cysteine peptidase inhibitor on expression of cathepsins B and L in implanted hepatoma Morris 5123 tumor model in Wistar rats. 15641152 2005