Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections
0.100 AlteredExpression group BEFREE However, because of low or absent coxsackievirus and adenovirus receptor levels on the surface of many kinds of tumor cells, the efficiency of adenovirus infection of target tumor cells may be low. 28407709 2020
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections
0.100 Biomarker group BEFREE These data reinforce the importance of CAR<sup>Ex8</sup> in apical adenovirus infection and provide a new model cell line to probe isoform specific biological functions of CAR. 31394408 2019
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections
0.100 AlteredExpression group BEFREE Susceptibility of prostate cancer cells LNCaP, PC3, and DU145 to adenovirus infection was associated with CAR expression. 26799485 2016
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections
0.100 Biomarker group BEFREE Adenoviruses are common pathogens.The localization of their receptors coxsackievirus and adenovirus receptor, and desmoglein-2 in cell-cell junction complexes between polarized epithelial cells represents a major challenge for adenovirus infection from the apical surface. 25723153 2015
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections
0.100 AlteredExpression group BEFREE Expression of an engineered soluble coxsackievirus and adenovirus receptor by a dimeric AAV9 vector inhibits adenovirus infection in mice. 25786873 2015
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections
0.100 Biomarker group BEFREE In contrast, the PDZ1 domain is able to rescue CAR(Ex8) and adenovirus infection from MAGI-1-mediated suppression. 22718816 2012
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections
0.100 Biomarker group BEFREE We hypothesized that cigarette smoke exposure increases epithelial susceptibility to adenovirus infection by increasing the abundance of apical CAR. 23166798 2012
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections
0.100 Biomarker group BEFREE Thus, although a cell type may be resistant to adenovirus infection, it is impossible to know whether it is due to a deficiency, as both CAR absence and inaccessibility are barriers to adenovirus-mediated gene transfer. 21918008 2012
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections
0.100 AlteredExpression group BEFREE This may indicate that CAR expression contributes to the efficacy of adenovirus infection and the antitumor activity of telomelysin in early stages of treatment. 20043095 2010
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections
0.100 Biomarker group LHGDN Complement component C1q and anti-hexon antibody mediate adenovirus infection of a CAR-negative cell line. 19115936 2008
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections
0.100 AlteredExpression group BEFREE FACS analysis and adenovirus infection assay revealed that there was a good correlation between the level of CAR expression and the transfection efficiency. 12529974 2003
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections
0.100 AlteredExpression group BEFREE These data show that the expression of CAR is closely related to susceptibility to adenovirus infection in human ovarian cancer cells. 11972385 2002
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections
0.100 AlteredExpression group BEFREE Thus, adenovirus infection and/or the maternal immune response to adenovirus infection induced the death of placental cell types that expressed CAR. 11207218 2001