Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
By logistic regression analysis, high fasting plasma glucose, smoking, high triglyceride and the Gly/Gly polymorphism in Arg389Gly ADRB1 all emerged as independent risk factors for hypertension.
|
29549925 |
2018 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Among Shors, the following factors increased AH risk: female sex, age, hypercholesterolemia, hyperbetacholesterinemia, hypertriglyceridemia, obesity (including transabdominal obesity), glucose intolerance, and the DD ACE, CT MTHFR, and AA ADRB1 genotypes; among the non-indigenous population, the main factors were age, hypercholesterolemia, hyperbetacholesterinemia, hypoalfacholesterinemia, hypertriglyceridemia, obesity (including transabdominal obesity), and ID ACE genotype.
|
29027816 |
2018 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
A new sight for detecting the ADRB1 gene mutation to guide a therapeutic regimen for hypertension based on a CeO<sub>2</sub>-doped nanoprobe.
|
27829563 |
2017 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The β1‑adrenergic receptor (AR) is the primary β‑AR subtype in the heart and is the target of metoprolol (Met), which is commonly used to treat angina and hypertension.
|
28000860 |
2017 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Associations between ADRB1 and CYP2D6 gene polymorphisms and the response to β-blocker therapy in hypertension.
|
25823457 |
2015 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The association of β1-adrenoreceptor gene Arg389Gly and Ser49Gly polymorphisms with hypertension has been exhaustively investigated; however, the studies have yielded inconsistent results.
|
23271137 |
2013 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The common polymorphisms producing changes in the β(1)-ARs, and their signaling pathways, have been associated with clinical outcomes in several studies in hypertension and heart failure.
|
22621216 |
2012 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We attempted replication of the top meta-analysis single nucleotide polymorphisms for these genes in the Global BPgen Consortium (n=34,433) and the Women's Genome Health Study (n=23,019) and found significant results for rs1801253 in ADRB1 (rs1801253" genes_norm="153;773">Arg389Gly), with the Gly allele associated with a lower mean systolic blood pressure (β: 0.57 mm Hg; SE: 0.09 mm Hg; meta-analysis: P=4.7×10(-10)), diastolic blood pressure (β: 0.36 mm Hg; SE: 0.06 mm Hg; meta-analysis: P=9.5×10(-10)), and prevalence of hypertension (β: 0.06 mm Hg; SE: 0.02 mm Hg; meta-analysis: P=3.3×10(-4)).
|
21444836 |
2011 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The first study showed that the Arg389Arg genotype of the ADRB1 gene was associated with risk of hypertension [odds ratio (OR) 1.77, 95% confidence interval (CI) 1.09-2.98; p=0.008], and the association was replicated in the second independent population (OR 1.65, 95% CI 1.07-2.89, p=0.01).
|
19743955 |
2009 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
The impact of alpha1-adrenoceptors up-regulation accompanied by the impairment of beta-adrenergic vasodilatation in hypertension.
|
19060223 |
2009 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Various studies suggest an association between beta(1)-adrenoceptor gene polymorphisms (Ser49Gly and Arg389Gly) and cardiovascular disorders, including hypertension, cardiomyopathy and congestive heart failure.2.
|
19673943 |
2009 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Association of beta 1-adrenergic receptor gene polymorphisms with left ventricular hypertrophy in human essential hypertension.
|
18298953 |
2008 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Numerous studies have demonstrated that beta(1)- and beta(2)-adrenergic receptor gene (ADRB1 and ADRB2) variants influence cardiovascular risk and beta-blocker responses in hypertension and heart failure.
|
18615004 |
2008 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Analysis of the association of the functional ADRB1 Arg389Gly variant with obesity and hypertension has given ambiguous results.
|
17335470 |
2007 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Association of CYP2D6 and ADRB1 genes with hypotensive and antichronotropic action of betaxolol in patients with arterial hypertension.
|
17635183 |
2007 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Nebivolol is a beta(1)-adrenergic receptor antagonist with vasodilating properties used in the treatment of hypertension.
|
17094780 |
2007 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our study aimed to confirm that beta(1)-adrenergic receptor polymorphisms affect the blood pressure response to metoprolol monotherapy in the Chinese population with hypertension.
|
16815314 |
2006 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In the future, codon 49 and 389 genotypes or beta(1)-adrenergic receptor haplotypes might be used to predict the diastolic blood pressure response to metoprolol in patients with hypertension.
|
12844134 |
2003 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Polymorphism in the beta(1)-adrenergic receptor gene and hypertension.
|
11447084 |
2001 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Antisense inhibition of beta(1)-adrenergic receptor mRNA in a single dose produces a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats.
|
10673262 |
2000 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Effects of renin-angiotensin blockade on sympathetic reactivity and beta-adrenergic pathway in the spontaneously hypertensive rat.
|
9260993 |
1997 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
No association with hypertension was evident, however, for polymorphisms of the growth hormone, low-density lipoprotein receptor, renal kallikrein, alpha 2- and beta 1-adrenoreceptor, atrial natriuretic factor and insulin genes.4.
|
8104754 |
1993 |