CYBB, cytochrome b-245 beta chain, 1536

N. diseases: 343; N. variants: 75
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 Biomarker disease BEFREE In LV tissues, protein expressions of inflammatory (tumor-necrosis factor-α/nuclear-factor-κB/interleukin-1ß/matrix-metalloprotianse-9), oxidative stress (NOX-1/NOX-2/oxidized protein), apoptotic (mitochondrial-Bax/cleaved-caspase-3/cleaved-PARP), fibrotic (transforming-growth factor-ß/Smad3), DNA/mitochondrial-damage (γ-H2AX/cytosolic-cytochrome-C) and heart failure (brain natriuretic peptide (BNP) levels displayed an opposite pattern to LVEF among the three groups (all p < 0.0001). 30404073 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 Biomarker disease BEFREE Si-Miao-Yong-An decoction ameliorates cardiac function through restoring the equilibrium of SOD and NOX2 in heart failure mice. 31228552 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 Biomarker disease BEFREE These results strongly suggest that Nox2 destabilization through disrupting TRPC3-Nox2 complex underlies attenuation of hyperglycemia-induced heart failure by TRPC6. 28790356 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 AlteredExpression disease BEFREE ED in HF rats is associated with decreased NO bioavailability in erectile tissue due to eNOS/nNOS dowregulation and NOX2 upregulation, as well as hypercontractility of the penis. 29095897 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 Biomarker disease BEFREE Overall, our findings suggest that Nox2 is an important source of ROS in the diaphragm of patients with HF and increases in levels of antioxidant enzymes are not sufficient to maintain normal redox homeostasis. 28119629 2016
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 Biomarker disease BEFREE Echocardiography revealed that ALDH-2(-/-)/gp91(phox-/-) mice were protected from ACA-overload-induced HF after 5 weeks of 2% EtOH-diet, demonstrating that NOX2-derived O2(•-) contributes to the development of ACM. 27624556 2016
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 Biomarker disease BEFREE Nox2 activation requires membrane translocation of the p47(phox) subunit and is linked to heart failure. 23553616 2013
CUI: C0018801
Disease: Heart failure
Heart failure
0.370 Biomarker disease CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010