|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
It is established that the immune system contributes to the development of SS hypertension and our laboratory has observed an enrichment of NOX2 subunits in infiltrating T cells.
|
31730933 |
2020 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Lancemaside A prevents hypertension in rats by inhibiting the activation of MAPK signalling and the impairment in nitric oxide bioavailability due to NOX2-mediated oxidative stress.
|
31350796 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These results showed that LMAE prevents Ang II-induced hypertension and vascular dysfunction through a reduction of oxidative stress linked to COX-2 and NOX-2 pathway and inhibition of calcium entry.
|
31183001 |
2019 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The results showed that HgCl<sub>2</sub> treatment accelerated the development of hypertension; reduced vascular reactivity to phenylephrine in MRAs; increased nitric oxide (NO) generation; promoted vascular dysfunction by increasing the production of reactive oxygen species (ROS), such as hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>); increased Gp91Phox protein levels and in situ levels of superoxide anion (O <sub>2</sub><sup>·-</sup> ); and reduced vasoconstrictor prostanoid production compared to vehicle treatment.
|
31338744 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These results identify a previously unrecognized role of Nox2 in modulating suppression of Tregs, which acts to enhance hypertension and cardiac remodeling.
|
29688896 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
TMEM16A Contributes to Endothelial Dysfunction by Facilitating Nox2 NADPH Oxidase-Derived Reactive Oxygen Species Generation in Hypertension.
|
28320851 |
2017 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Myeloid-specific Nox2 deletion had no effect on angiotensin II-induced hypertension, which, however, was blunted in Tie2-CreNox2KO mice, along with preservation of endothelium-dependent relaxation during angiotensin II stimulation.
|
28298457 |
2017 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
It also decreased the levels of superoxide, NOX2, NOX4 and mitochondrial MDA, and increased the levels of Cu/Zn‑SOD, mitochondrial SOD and GSH in the RVLM compared with the rats fed a high-salt diet and not treated with ALA. On the whole, our findings indicate that long‑term ALA supplementation attenuates hypertensive responses and cardiac hypertrophy by decreasing the expression of NAD(P)H subunits (NOX2 and NOX4), increasing the levels of mitochondrial bioenergetic enzymes, and enhancing the intracellular antioxidant capacity in the RVLM during the development of hypertension.
|
28035366 |
2017 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats.
|
27847271 |
2017 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Chronic infusion of epigallocatechin-3-O-gallate into the hypothalamic paraventricular nucleus attenuates hypertension and sympathoexcitation by restoring neurotransmitters and cytokines.
|
27659729 |
2016 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Nox2 depletion in gp91phox knockout mice inhibited AngII-induced cellular and mitochondrial O2(•-) and attenuated hypertension.
|
24053613 |
2014 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Circulating progenitor cells are increased in newly diagnosed untreated hypertensive patients with arterial stiffening but normal carotid intima-media thickness.
|
21593737 |
2011 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We demonstrated previously that, in mice with chronic angiotensin II-dependent hypertension, gp91phox-containing NADPH oxidase is not involved in the development of high blood pressure, despite being important in redox signaling.
|
18195161 |
2008 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Contribution of reactive oxygen species to the pathogenesis of left ventricular failure in Dahl salt-sensitive hypertensive rats: effects of angiotensin II blockade.
|
16685210 |
2006 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
In contrast to its action on ROS generation, gp91phox inactivation had no effect on development of hypertension or cardiac hypertrophy in TTRhRen mice, although interstitial fibrosis was reduced.
|
15753233 |
2005 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
Superoxide dismutase, catalase, glutathione peroxidase and NADPH oxidase in lead-induced hypertension.
|
12472782 |
2003 |