|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Multiple logistic regression adjusted for age and sex showed that subjects carrying rs7897633-A (PRKG1), rs434082-A (SLC8A1) and rs1042714-G (ADRB2) risk alleles had 1.83-, 2.84- and 2.40-fold increased risk for salt-sensitive hypertension, respectively.
|
28446801 |
2017 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
In conclusion, CST-364Ser allele enhanced the risk for hypertension in human populations, possibly via diminished endothelial NO production because of altered interactions of CST-364Ser peptide with ADRB2 as compared with CST-WT.
|
27324226 |
2016 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Association of the ADRB2 (rs2053044) polymorphism and angiotensin-converting enzyme-inhibitor blood pressure response in the African American Study of Kidney Disease and Hypertension.
|
26111150 |
2015 |
|
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Evidence of interaction between the genetic loci of ADRB2 and NOS3 points to varied clinical, biochemical, and expression levels and a role in hypertension susceptibility.
|
25159081 |
2015 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Our findings offer an opportunity for prediction of hypertension in elderly Lebanese individuals that carry a genetic combination of Asp/Asp genotype and Gly allele in eNOS and ADRB2 genes.
|
24623205 |
2014 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Beta 2 (β2) adrenoceptor gene polymorphisms have been associated with hypertension in different populations with conflicting results.
|
24782128 |
2014 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
ADRB2 Thr164Ile is associated with increased blood pressure, increased frequency of hypertension and increased risk of IHD amongst women in the general population.
|
21883537 |
2012 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The results indicated that 46A/G polymorphism in the β2-AR gene was associated with hypertension susceptibility in Han Chinese population.
|
22763735 |
2012 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
This study aims to check for the association of genetic polymorphisms of the cytochrome P450 2J2 (CYP 2J2) and beta-2-adrenergic receptor (ADRB2) genes with hypertension among Saudi subjects.
|
22731644 |
2012 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In a high-obesity and high-hypertension risk population with ancestry in common with African Americans, genetic variation defined by 2 common ADRB2 amino acid substitutions was not associated with body composition or hypertension.
|
20727557 |
2011 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Association study of the β2-adrenergic receptor gene polymorphisms and hypertension in the Northern Han Chinese.
|
21483652 |
2011 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Variants of beta2-adrenergic receptor gene (ADRB2) have been associated with dyslipidemia, IR, and hypertension, but its effect on GGT secretion is not known.
|
20537997 |
2010 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Beta(2)-adrenergic receptor (beta2-AR) is a susceptibility locus for hypertension, and polymorphisms at this site relate to salt sensitivity and low plasma renin activity (PRA).
|
20519561 |
2010 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The present study did not find consistent evidence for an association of ADRB2 variants with either obesity or hypertension when variations were analysed in a case-control study.
|
19779622 |
2009 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The odds ratio for the presence of hypertension in individuals having the Gly/Gly genotype of ADRB2 compared with those having the other genotypes (Arg/Arg and Arg/Gly) was 2.87.
|
19373110 |
2009 |
|
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Participants with hypertension had significantly less-expressed beta-2 adrenoceptor gene (2.76-fold, p<.05) compared to normotensive participants.
|
19254913 |
2009 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
The opposite effect of the polymorphism on cognition in the two age classes observed in the different cohorts resembles the effect of ADRB2 on hypertension, which also has been reported to be age dependent.
|
18855131 |
2009 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
LHGDN |
Job stress, gene polymorphism of beta2-AR, and prevalence of hypertension.
|
18714823 |
2008 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Numerous studies have demonstrated that beta(1)- and beta(2)-adrenergic receptor gene (ADRB1 and ADRB2) variants influence cardiovascular risk and beta-blocker responses in hypertension and heart failure.
|
18615004 |
2008 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Recently, we have shown that the Glu27 beta(2)AR variant is strongly associated with cardiac hypertrophy in hypertension.
|
17178264 |
2006 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The beta-2 adrenergic receptor variants were not associated with hypertension per se.
|
17015767 |
2006 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The results indicate that variants at the ADRB2 locus may play a role in the pathophysiology of hypertension specifically in the Yi minority group.
|
16685203 |
2006 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
LHGDN |
The sympathetic nervous system is a key player in blood pressure control and functional genetic variants of the beta-2 adrenergic receptor (B2AR) have been identified and implicated in the pathogenesis of hypertension.
|
16467650 |
2006 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
LHGDN |
The results indicate that variants at the ADRB2 locus may play a role in the pathophysiology of hypertension specifically in the Yi minority group.
|
16685203 |
2006 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
LHGDN |
These results indicate that the Gly16 and Gln27 alleles of the ADRB2 gene confer an increased risk for stage-2 hypertension in this northern Han Chinese population.
|
15638826 |
2005 |