|
Obesity
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, (1) obesity does not alter the β2-AR-mediated decrease of the innate response of macrophages and (2) regular exercise can revert the inhibitory effect of terbutaline on the phagocytic activity of macrophages, although obesity seems to hinder this immunophysiological adaptation.
|
31717554 |
2019 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A total of 107 unrelated overweight/obese individuals were genotyped for two ADRB2 non-synonymous polymorphisms: rs1042713" genes_norm="154">Arg16Gly (rs1042713) and Gln27Glu (rs1042714).
|
29331538 |
2018 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Obesity risk was significantly associated to 6 SNPs (ADRB2 rs1042713, APOB rs512535, PPARA rs1800206, TNFA rs361525, TRHR rs7832552 and rs16892496) after adjustment by gender, age, ancestry, VO<sub>2max</sub> , and ME.
|
28294290 |
2017 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The PubMed (1950-2014), Embase (1974-2014), and China National Knowledge Infrastructure (CNKI, 1994-2014) databases were searched using the search terms ("Beta2-adrenergic receptor", "β2-adrenergic receptor" or "ADRB2"), "polymorphism," and "obesity".
|
24960039 |
2014 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study indicates that the ADRB2 rs1042714 SNP may contribute to the risk of obesity and predict obesity-related metabolic traits such as BMI, triglyceride, and systolic blood pressure in Taiwanese subjects.
|
24322328 |
2014 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present results suggest that rs34623097-A, which would lead to lower expression of ADRB2, contributes to the onset of obesity in the Oceanic populations.
|
23229733 |
2013 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ADRB2 G-G haplotype associated with breast cancer risk among Hispanic and non-Hispanic white women: interaction with type 2 diabetes and obesity.
|
22864926 |
2012 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, hypertensive cases, whether being isolated or associated with obesity and/or diabetes, showed a nonsignificant difference from controls in relation to all genotypic variants related to the ADRB2 G46A polymorphism (p>0.05).
|
22731644 |
2012 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The Glu27 allele in ADRB2 and the Arg64 allele in ADRB3 are associated with abdominal obesity and early onset of non-insulin-dependent diabetes mellitus (NIDDM) in many ethnic groups.
|
22937051 |
2012 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
There is some evidence supporting "possible" candidate genes that may affect these responses to exercise training: APO E and CETP for plasma lipoprotein-lipid profiles; eNOS, ACE, EDN1, and GNB3 for blood pressure; PPARG for type 2 diabetes phenotypes; and FTO and BAR genes for obesity-related phenotypes.
|
21565989 |
2011 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
The β(2)-adrenergic receptor (ADRB2) mediates obesity, cardiorespiratory fitness, and insulin resistance.
|
20829805 |
2011 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CART analysis showed that smoking parents who overate and carried the Arg allele, ADRB2 R16G, had an odds ratio (OR) of 11.7 (95% confidence interval (CI), 2.13-64.04) for obesity compared to non-smoking parents who had none of these factors.
|
22094842 |
2011 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Together, our findings suggest evidence for a two-locus interaction between the LEPR Gln223Arg and ADRB2 Arg16Gly variants in the risk of overweight/obesity, and highlight further the importance of multilocus effects in the genetic component of obesity.
|
21233811 |
2011 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Classic tissue effects of β(2)-adrenergic receptor activation include skeletal muscle glycogenolysis and vascular smooth muscle relaxation, factors relevant to obesity and hypertension, respectively.
|
20727557 |
2011 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ADRB2 and LEPR gene polymorphisms: synergistic effects on the risk of obesity in Japanese.
|
21233812 |
2011 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We evaluated Gln27Glu polymorphism in the β2AR gene in obese Saudi populations to investigate the association of β2AR gene with obesity and other related metabolic parameters.
|
20738880 |
2010 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Proposed test statistics are applied to NHANES III data to test for associations between the locus ADRB2 (rs1042713) and obesity, between VDR (rs2239185) and high blood lead level, and between TGFB1 (rs1982073) and asthma.
|
19745160 |
2010 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present study did not find consistent evidence for an association of ADRB2 variants with either obesity or hypertension when variations were analysed in a case-control study.
|
19779622 |
2009 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To further elucidate the role of these genes in the pathophysiology of obesity the present study investigated associations between certain polymorphisms in ADRB2 and ADRB3 and parameters of carbohydrate and lipid metabolism in a population of African origin.
|
18393130 |
2008 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To explore whether mutations in the BAR-1 gene contribute to morbid obesity in Japanese, we scanned for mutations in the coding sequence of the gene in 50 morbid obese [body mass index (BMI)>==35.0kg/m(2); 99.7th percentile] Japanese subjects.
|
18346809 |
2008 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of published studies, included if subjects were genotyped at either codon 27 ("B27") or codon 16 ("B16") of the ADRB2 gene and both obese and nonobese subjects were selected, based on a reported cutoff BMI limit.
|
19186333 |
2008 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our two step SSCP method for beta2AR haplotyping is simple, accurate and cost effective for studying large populations and may be a useful tool for easy and accurate identification of haplotype I which appears to have a protective role against developing obesity.
|
17303378 |
2007 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interactions were detected between ADRA2A C-1291G and ADRB2 Gln27-->Glu variants for obesity in African Americans and between ADRA2A C-1291G SNP and ADBR1 haplotype for obesity in whites.
|
17512307 |
2007 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
We investigated the role of three polymorphisms, and related haplotypes of the beta(2)-AR in the obesity and related traits in a cohort of overweight/obese subjects.
|
16251889 |
2006 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
CTD_human |
beta2-adrenergic receptor polymorphisms and salbutamol-stimulated energy expenditure.
|
15687340 |
2005 |