Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, three representative DL-PCBs, i.e., PCB 77, PCB 126, and 3,4,4',5-tetrachlorobiphenyl (PCB 81), were investigated on their genotoxicity in Chinese hamster V79-derived cell lines genetically engineered for the expression of human CYP1A1, 1A2 and 1B1, and in the human hepatoma C3A cell line, which endogenously expresses various CYPs.
|
31733235 |
2020 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In human hepatocellular carcinoma cells (HepG2) with aryl hydrocarbon receptor (AhR) or specificity protein 1 (Sp1) knockdown, we confirmed that AhR and Sp1 are involved in basal CYP1A1 expression.
|
31199573 |
2019 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activated thyroid hormone receptor modulates dioxin-inducible aryl hydrocarbon receptor-mediated CYP1A1 induction in human hepatocytes but not in human hepatocarcinoma HepG2 cells.
|
28478156 |
2017 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cell growth was measured in mouse hepatoma Hepa-1 wild-type and cytochrome P4501A1 (CYP1A1)-deficient c37 cells.
|
28289825 |
2017 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Subjects with CYP1A1 gene variants (m1 and m3) had no significant risk to develop cirrhosis or HCC compared to control group.
|
27271262 |
2016 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis results showed no significant association between the CYP1A1 3801 T>C polymorphism and HCC risk.
|
25730047 |
2015 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the regulation of the expression of genes encoding the drug-metabolizing enzymes CYP1A1 and CYP1A2 in 3D spheroids comprised of cells of the human hepatocellular carcinoma cell JHH1, Huh7, and HepG2.
|
26643992 |
2015 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
For cytochrome P450 enzymes 1 (CYP1) family, the expression of CYP1A2 was decreased 90% in HCC, 80% in alcoholic cirrhosis, and 65% in severe cirrhosis.
|
25024626 |
2014 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, available data collected by the study failed to reveal remarkable associations of GC or HC with CYP1A1 Ile/Val genetic polymorphisms and EC, GC or CC with CYP1A1 MspI genetic polymorphisms.
|
24969905 |
2014 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We also demonstrated that IL-6 can induce CYP1B1 expression independently of CYP1A1, in a human hepatocellular liver carcinoma cell line.
|
23087145 |
2012 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, a meta-analysis was performed to clarify the associations of polymorphisms in CYP1A1 gene with HCC risk.
|
22297691 |
2012 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Genotoxicity of 7H-dibenzo[c,g]carbazole and its tissue-specific derivatives in human hepatoma HepG2 cells is related to CYP1A1/1A2 expression.
|
21809388 |
2011 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, we examined the ability of three different camel urines (virgin, lactating, and pregnant source) to modulate a well-known cancer-activating enzyme, the cytochrome P450 1a1 (Cyp1a1) in murine hepatoma Hepa 1c1c7 cell line.
|
20883769 |
2011 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have previously shown that the p38 MAPK inhibitor SB203580 (SB) significantly induced Cyp1a1 gene expression at the mRNA and activity levels, whereas it dramatically inhibited the induction of Cyp1a1 by TCDD in murine hepatoma Hepa 1c1c7 cells.
|
21732638 |
2011 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined the association between HCC and four selected tagging single nucleotide polymorphisms (SNPs) of CYP1A1, and the risk of CYP1A1 haplotypes/diplotypes in 1006 pathologically confirmed HCC patients and 1015 cancer-free controls, from a Han Chinese population.
|
19110417 |
2009 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conducted a case-control study, including 209 incident cases with hepatocellular carcinoma (HCC) and two different control groups [275 hospital controls and 381 patients with chronic liver disease (CLD) without HCC], to investigate whether CYP1A1, CYP1A2, CYP2A6, CYP2E1, GSTM1 and NAT2 polymorphisms are related to the risk of HCC with any interaction with cigarette smoking.
|
19643819 |
2009 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, based on another hypothesis in which estrogen metabolites can directly cause DNA damage and affect tumor initiation, we examined whether the polymorphisms of the estrogen-metabolizing enzymes (EME), which are involved in biogenesis (CYP17, CYP19), bioavailability (CYP1A1, CYP1B1), and degradation (catechol-O-methyltransferase) of the estrogens, have any bearing on the risk for hepatocellular carcinoma.
|
19064581 |
2008 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SK-HEP-1 to dioxin.
|
16054781 |
2005 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found that the risk of HCC was elevated in women harboring either heterozygous or homozygous variants of the CYP1A1 gene and the respective OR (and 95% confidence interval) were 6.61 (1.35, 32.43) and 12.00 (1.73, 83.46).
|
15341023 |
2004 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
We found that the risk of HCC was elevated in women harboring either heterozygous or homozygous variants of the CYP1A1 gene and the respective OR (and 95% confidence interval) were 6.61 (1.35, 32.43) and 12.00 (1.73, 83.46).
|
15341023 |
2004 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Frequencies of the CYP1A1 highly inducible alleles, MspI m2 and Val, were increased in liver disease patients compared with carriers; no specific association with HCC was found.
|
12569554 |
2003 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Clinically relevant concentrations (0.25-5 microM) of As2O3 were demonstrated to inhibit CYP1A activity in primary human hepatocytes and hepatoma Hep3B and HepG2 cells coexposed to 3-methylcholanthrene (3MC), benzo(a)pyrene, or dioxin and the metalloid for 24 h. Inhibition reached 50 and 90% in Hep3B cells treated with 1 and 5 microM As2O3, respectively, and was not due to direct interaction of the metalloid with CYP1A1.
|
12490585 |
2003 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In human cells, such as HepG2 (human hepatocarcinoma), MCF-7 (human breast adenocarcinoma cell line), and HL-60 (human promyelocytic cell line), the expression of CYP1A1 mRNA was also induced by EA4 treatment.
|
11710520 |
2001 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Induction of cytochrome P450 1A1 in human hepatoma HepG2 cells by 6-nitrochrysene.
|
11033235 |
2000 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
SK-Hep-1 is the first human hepatoma line described with a demonstrable defect in CYP1A1 or its regulation.
|
11147830 |
2000 |