Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Heterozygote carriers of SNPs in CYP1A2 1545T>C, -164C>A and -740T>G; CYP2A6 -47A>C; MDR1 3435T>C; NAT1 1088T>A and 1095A>C; GSTA2 S112T; GSTM3 V224I and MTHFR A222V had altered risk of developing lung cancer.
|
17259654 |
2007 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
CTD_human |
In this study, immunohistochemistry and in situ hybridization (ISH) for CYP2A6 with human lung cancer tissues (n=31) obtained by surgical resection showed significantly higher immunoreactivity in the cases with lymph node metastasis.
|
17549345 |
2007 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
CTD_human |
Other mutant alleles reducing the CYP2A6 activity, besides CYP2A6*4C, also reduced the risk of lung cancer in smokers, particularly of squamous-cell carcinoma and small-cell carcinoma, both smoking-related cancers.
|
16176798 |
2005 |
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Other mutant alleles reducing the CYP2A6 activity, besides CYP2A6*4C, also reduced the risk of lung cancer in smokers, particularly of squamous-cell carcinoma and small-cell carcinoma, both smoking-related cancers.
|
16176798 |
2005 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that the CYP2A6 is one of the principal determinants affecting not only smoking behavior but also susceptibility to tobacco-related lung cancer.
|
15308589 |
2004 |
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No association was observed between CYP2A6 genotype and risk of lung cancer.
|
14633739 |
2003 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taking these results into account, CYP2A6 is an enzyme enhancing lung cancer risk.
|
12214673 |
2002 |
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The subjects with lung cancer were additionally divided into three groups according to the histological classification of the cancer and examined for an association with the CYP2A6 polymorphism.
|
12223434 |
2002 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
NNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone); current studies are investigating the role of CYP2A6 in risk for lung cancer.
|
11805739 |
2002 |
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the CYP2A6 alleles vary considerably among different ethnic populations, which may partially explain the interethnic variability found in CYP2A6-related metabolic activity (e.g. nicotine metabolism), behaviors (i.e. smoking) and disease (i.e. lung cancer).
|
12406643 |
2002 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
CTD_human |
Taking these results into account, CYP2A6 is an enzyme enhancing lung cancer risk.
|
12214673 |
2002 |
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This effect was mainly limited to squamous-cell carcinoma and to non-smokers, although a joint effect of CYP2A6 deletion and tobacco smoking on lung cancer risk was observed among heavy smokers.
|
11241319 |
2001 |
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this Caucasian population, we found neither a relation between genetically impaired nicotine metabolism and cigarette consumption, nor any modification of lung cancer risk related to the presence of defective CYP2A6 alleles (odds ratio = 1.1, 95% confidence interval = 0.7-1.9).
|
11207029 |
2001 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
CTD_human |
This effect was mainly limited to squamous-cell carcinoma and to non-smokers, although a joint effect of CYP2A6 deletion and tobacco smoking on lung cancer risk was observed among heavy smokers.
|
11241319 |
2001 |
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Studies in Japanese suggest that CYP2A6 poor metabolizer genotypes result in altered nicotine kinetics and may lower cigarette smoking elicited lung cancer risk, whereas similar studies in Caucasian populations have not revealed any clear associations between variant CYP2A6 genotypes and smoking behaviour or lung cancer predisposition.
|
11678779 |
2001 |
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The frequency of CYP2A6 gene whole deletion was significantly lower in the lung cancer patients than that of healthy volunteers.
|
10517986 |
1999 |
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that deficient CYP2A6 activity due to genetic polymorphism reduces lung cancer risk.
|
10441482 |
1999 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
CTD_human |
These data suggest that deficient CYP2A6 activity due to genetic polymorphism reduces lung cancer risk.
|
10441482 |
1999 |