|
Left ventricular diastolic dysfunction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The GRK2-mRNA level in PBMCs of DM with LVDD was significantly higher than in DM control without LVDD.
|
31680450 |
2020 |
|
Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CP-25 attenuates arthritis progression in animal models by inhibiting G protein-coupled receptor kinase 2 (GRK2) membrane expression.
|
30557832 |
2019 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
G-protein coupled receptor kinase 2 safeguards epithelial phenotype in Head and Neck Squamous Cell Carcinomas.
|
31850518 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
The Influence of β-Adrenergic Receptor Kinase-1 on Stroke-induced Immunodeficiency Syndrome.
|
29601376 |
2019 |
|
Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we report that GRK2 knockdown slowed cell growth, diminished proliferation, and enhanced cisplatin- and etoposide-induced apoptosis in medulloblastoma cell lines UW228-2 and Daoy.
|
31554835 |
2019 |
|
Tongue Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We uncover that G-protein-coupled receptor kinase-2 (GRK2) expression is reduced in undifferentiated, high-grade human HNSCC tumors, whereas its silencing in model human HNSCC cells is sufficient to trigger epithelial-to-mesenchymal transition (EMT) phenotypic features, an EMT-like transcriptional program and enhanced lymph node colonization from orthotopic tongue tumors in mice.
|
31850518 |
2019 |
|
Childhood Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we report that GRK2 knockdown slowed cell growth, diminished proliferation, and enhanced cisplatin- and etoposide-induced apoptosis in medulloblastoma cell lines UW228-2 and Daoy.
|
31554835 |
2019 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we report that GRK2 knockdown slowed cell growth, diminished proliferation, and enhanced cisplatin- and etoposide-induced apoptosis in medulloblastoma cell lines UW228-2 and Daoy.
|
31554835 |
2019 |
|
Benign neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mean serum levels of Ang II and TNF-α in normal subjects and patients with benign liver tumors (BLTs) and HCC were evaluated by enzyme-linked immunosorbent assay (ELISA), and liver samples from the patients with HCC and HCC mice were used to assess the protein levels of both cytokines, their major receptors and GRK2.
|
30712649 |
2019 |
|
physical symptom
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
βARK1 was significantly associated with HFSPS scores (β = 0.22 ± 0.10, p = 0.038), adjusting for other predictors of physical symptoms (model R<sup>2</sup> = 0.250, F(7, 70) = 3.34, p = 0.004).
|
29803296 |
2019 |
|
Heart Failure, Systolic
|
0.010 |
Biomarker
|
disease |
BEFREE |
GRK2 appears a promising target, given its established role in insulin resistance and in systolic heart failure.
|
30934608 |
2019 |
|
Squamous cell carcinoma of the head and neck
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that GRK2 safeguards the epithelial phenotype, whereas its downregulation contributes to the activation of EMT programs in HNSCC.This article is protected by copyright.All rights reserved.
|
31850518 |
2019 |
|
Regurgitation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Therefore, changes in the expression of β2-AR and GRK2 in PBMC of PR patients, could be considered as potential biomarkers to determine clinical decisions.
|
30837872 |
2019 |
|
Autoimmune arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
CP-25 reverses prostaglandin E4 receptor desensitization-induced fibroblast-like synoviocyte dysfunction via the G protein-coupled receptor kinase 2 in autoimmune arthritis.
|
30643209 |
2019 |
|
Contact Dermatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Glutamine application resulted in a rapid and strong expression of GRK2 in not only dinitrochlorobenzene-induced CD (within 10 minutes) but also cultured rat dorsal root ganglion cells, F11 (within 1 minute).
|
29530536 |
2018 |
|
Congenital Heart Defects
|
0.010 |
GeneticVariation
|
group |
BEFREE |
However, germ-line (but not cardiomyocyte-specific) GRK2 deletion provoked lethal fetal heart defects, suggesting an unexplained role for GRKs in heart development.
|
29969579 |
2018 |
|
Ventricular Septal Defects
|
0.010 |
Biomarker
|
group |
BEFREE |
GRK2/5/6 triple null mice at E14.5 exhibited left and right heart blood intermixing through single atrioventricular valves or large membranous ventricular septal defects.
|
29969579 |
2018 |
|
Herpes Simplex Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
The effect of herpes simplex virus (HSV)-GRK2 amplicons to restore GRK2 levels or of an Epac inhibitor on PGE<sub>2</sub> allodynia in primed mice was examined.
|
29922165 |
2018 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target.
|
30206219 |
2018 |
|
Hereditary hemochromatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The kinase GRK2 has been linked to the clinically important Hedgehog (HH) signaling pathway, where it is paradoxically required for signal transduction yet also promotes internalization and degradation of the critical HH signal transducer Smoothened.
|
29438011 |
2018 |
|
Sepsis-Associated Encephalopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Altogether, these results uncover the novel role for GRK2 in regulating cellular oxidative and nitrosative stress during inflammation and suggest that GRK2 may have a potential as an intriguing therapeutic target to prevent or treat SAE.
|
29500815 |
2018 |
|
Rebound hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
To test the effects of GRK2 inhibitotr, we measured blood pressure by using a tail-cuff system in diabetic mice in which rebound hypertension was induced by withdrawal after clonidine treatment and measured vascular responses in isolated aortas from these mice.
|
29463871 |
2018 |
|
Episodic ataxia type 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In rat EAM, treatment with gallein effectively improved survival and cardiac function, suppressed cardiac remodeling, and further attenuated myocardial protein expression of GRK2 as well as high mobility group box (HMGB)1 and its cascade signaling proteins.
|
30024944 |
2018 |
|
Takotsubo Cardiomyopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Sequential biopsies in the recovery-phase for two patients with TTS revealed that membrane expression of GRK2 and β-arrestin2 faded over time.
|
30143703 |
2018 |
|
Laryngeal cleft
|
0.010 |
Biomarker
|
disease |
BEFREE |
To counteract vasoconstrictor-induced contraction, GPCR/PLC signaling can be desensitized by G protein-coupled receptor kinases (GRKs), with GRK2 playing a predominant role in isolated arterial smooth muscle cells.
|
29980659 |
2018 |