Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.010 Biomarker disease BEFREE Atomoxetine is a treatment for attention-deficit/hyperactivity disorder and is primarily eliminated via cytochrome P4502D6 (CYP2D6). 12621383 2003
CUI: C3544321
Disease: Treatment-resistant schizophrenia
Treatment-resistant schizophrenia 		0.010 GeneticVariation disease BEFREE A patient with treatment-resistant schizophrenia and cytochrome P4502D6 gene duplication. 11940091 2002
CUI: C0001824
Disease: Agranulocytosis
Agranulocytosis 		0.010 GeneticVariation disease BEFREE Clozapine-induced agranulocytosis and hereditary polymorphisms of clozapine metabolizing enzymes: no association with myeloperoxidase and cytochrome P4502D6. 11147929 2000
CUI: C0017551
Disease: Gilbert Disease (disorder)
Gilbert Disease (disorder) 		0.010 Biomarker disease BEFREE Gilbert's syndrome, a genetic deficiency in bilirubin UDP-glucuronosyltransferase (UGT1A1), may dispose to increased toxicity of propafenone in poor metabolizers (PMs) of cytochrome P4502D6 because glucuronidation of propafenone is the major metabolic pathway for drug elimination in PMs. 10850406 2000
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.010 Biomarker group BEFREE Alternative splicing patterns of CYP2D genes in human brain and neurodegenerative disorders. 10534269 1999
CUI: C4511452
Disease: Sporadic Parkinson disease
Sporadic Parkinson disease 		0.010 GeneticVariation disease BEFREE Four polymorphic sites (C/T188, C/T2938, G/C4268, G/A1934) in the cytochrome P4502D6 (debrisoquine 4-hydroxylase) gene were investigated for their association with sporadic Parkinson's disease (PD). 10210913 1999
CUI: C1851958
Disease: Lewy Body Variant of Alzheimer Disease
Lewy Body Variant of Alzheimer Disease 		0.010 GeneticVariation disease BEFREE Association of CYP2D microsatellite polymorphism with Lewy body variant of Alzheimer's disease. 9633694 1998
CUI: C3203671
Disease: CYP2D6 polymorphism
CYP2D6 polymorphism 		0.010 GeneticVariation disease BEFREE Taking this new information into account, we have reconsidered the potential influence of CYP2D6 polymorphism in lung cancer susceptibility by performing a comparative analysis of the overall mutational spectrum of CYP2D6 and of the rearrangements of CYP2D in 249 patients with lung cancer and in 265 control individuals matched on age, sex, hospital and residence area. 9511176 1998
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.010 AlteredExpression group BEFREE Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues. 9205060 1997