|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An association study of debrisoquine hydroxylase (CYP2D6) polymorphisms in schizophrenia.
|
7712118 |
1994 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study used the association approach to test the hypothesis that mutations in the genes for debrisoquine 4-hydroxylase (CYP2D6) and the dopamine transporter (DAT) confer susceptibility to schizophrenia.
|
7485241 |
1995 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic polymorphisms for drug metabolism (CYP2D6) and tardive dyskinesia in schizophrenia.
|
9713905 |
1998 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together with previous results, no major effect appears to be caused by the CYP2D6 gene on schizophrenia.
|
9564684 |
1998 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Effects of the CYP2D6*10 allele on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia.
|
10096261 |
1999 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common CYP2D6 mutant alleles were not associated with schizophrenia or with disease symptoms, antipsychotic-related adverse effects, or attitudes toward treatment.
|
10610012 |
1999 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The authors we investigated the relationship between plasma levels of haloperidol (HAL) and the number of CYP2D6*10 (*10) alleles in 66 Japanese inpatients with schizophrenia (male = 61, female = 5) on HAL.
|
10942177 |
2000 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data suggest that the CYP2D6 gene may not be a susceptibility gene for schizophrenia in Chinese schizophrenic patients.
|
11702057 |
2001 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Abnormal movements and tardive dyskinesia in smokers and nonsmokers with schizophrenia genotyped for cytochrome P450 2D6.
|
12432967 |
2002 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Effects of CYP2D6 genotypes on plasma concentrations of risperidone and enantiomers of 9-hydroxyrisperidone in Japanese patients with schizophrenia.
|
12616663 |
2003 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Effects of various CYP2D6 genotypes on the steady-state plasma concentrations of risperidone and its active metabolite, 9-hydroxyrisperidone, in Japanese patients with schizophrenia.
|
12766554 |
2003 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Reported herein are two NMS patients with schizophrenia who were found to possess a CYP2D6 gene deletion allele (CYP2D6*5).
|
16048458 |
2005 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CYP2D6 loss of function alleles may predispose to tardive dyskinesia in patients with schizophrenia under treatment, but bias cannot be excluded.
|
15861039 |
2005 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
CYP2D6 loss of function alleles may predispose to tardive dyskinesia in patients with schizophrenia under treatment, but bias cannot be excluded.
|
15861039 |
2005 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the CYP1A2 and CYP2D6 polymorphisms are not likely to play a major role in the development of polydipsia in schizophrenia, although further studies testing other alleles of CYP1A2 and CYP2D6 using different ethnic populations are warranted.
|
16775389 |
2006 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The C100T polymorphism of the CYP2D6 gene and the C163A polymorphism of the CYP1A2 gene may be associated with neuroleptic drug-induced tardive dyskinesia in Chinese patients with schizophrenia.
|
16490169 |
2006 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to evaluate the influence of CYP2D6 genotype on psychopathological symptoms and the occurrence of EPS in Slovenian outpatients with schizophrenia or schizoaffective disorder in stable remission, receiving long-term maintenance antipsychotic treatment.
|
16478753 |
2006 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
LHGDN |
The present study shows a lower frequency of PMs in schizophrenic patients than in healthy volunteers supporting the hypothesis of a potential role of CYP2D6 in the vulnerability to schizophrenia.
|
17325735 |
2007 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Serum prolactin levels, plasma risperidone levels, polymorphism of cytochrome P450 2D6 and clinical response in patients with schizophrenia.
|
17715206 |
2007 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In keeping with this, CYP2D6 may influence, not only variability to drug response, but also vulnerability to disease in schizophrenia patients.
|
18034624 |
2007 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present study shows a lower frequency of PMs in schizophrenic patients than in healthy volunteers supporting the hypothesis of a potential role of CYP2D6 in the vulnerability to schizophrenia.
|
17325735 |
2007 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
In keeping with this, CYP2D6 may influence, not only variability to drug response, but also vulnerability to disease in schizophrenia patients.
|
18034624 |
2007 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We tested whether substance abuse disorder and suicidal behavior were associated with the CYP2D6 and CYP2C19 genotypes among patients with schizophrenia.
|
18520596 |
2008 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Clinical significance of a CYP2D6 poor metabolizer--a patient with schizophrenia on risperidone treatment.
|
18806696 |
2008 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We identified the null variants *3,*4,*5,*6,*7 and *8 of the CYP2D6 gene [encoding for cytochrome P450 (debrisoquine hydroxylase)] in a group of 84 chronic-stay psychiatric inpatients with severe schizophrenia or related disorders and receiving treatment with one or more CYP2D6 substrates for years.
|
18425996 |
2008 |