Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The frequency of fifteen genotypes of CYP2D6 (debrisoquine 4-hydroxylase) in 53 patients with Parkinson's disease was determined by the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses and compared with the findings in 72 healthy controls.
|
1349052 |
1992 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Individuals with a metabolic defect in the cytochrome P450 CYP2D6-debrisoquine hydroxylase gene with the poor metaboliser phenotype had a 2.54-fold (95% Cl 1.51-4.28) increased risk of Parkinson's disease.
|
1350805 |
1992 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the HhaI polymorphism in the CYP2D6 gene is a part of the molecular basis of Parkinson's disease.
|
7903297 |
1993 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease.
|
8291573 |
1993 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that the CYP2D6 locus is not the major determinant of genetic susceptibility in familial Parkinson's disease.
|
8057112 |
1994 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphism of cytochrome P450 2D6 in idiopathic Parkinson disease and diffuse Lewy body disease.
|
9316701 |
1994 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analyses of the cytochrome P450 CYP2D6-debrisoquine 4-hydroxylase mutant B allele, a susceptibility gene for PD, revealed a higher representation of this allele in the Lewy body variant of AD than in pure AD or non-AD without Lewy bodies.
|
7818242 |
1995 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest the combined effect of environmental toxins and CYP2D6 in the cause of Parkinson's disease.
|
7697946 |
1995 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Molecular genetic studies of the cytochrome P450 system enzyme CYP2D6, which hydroxylates debrisoquine, have indicated an excess of mutant alleles in large series of patients with Parkinson's disease (PD) when compared with controls.
|
7651442 |
1995 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We analyzed a genetic risk factor of Alzheimer's disease (AD), apolipoprotein E, hypothesized to be linked to NFT formation, and a genetic risk factor of Parkinson's disease (PD), CYP2D6 mutation, linked to slower metabolism of exogenous toxins, in Chamorro, Guam individuals with and without PDC.
|
8797479 |
1996 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In contrast with the results from genotyping studies conducted among patients with an older age at onset, there were no significant differences in CYP2D6 allelic frequencies between young-onset PD cases and controls.
|
8710083 |
1996 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results argue against a significant role of the CYP2D6 gene in the aetiology of sporadic and familial idiopathic parkinsonism in this patient population.
|
8937349 |
1996 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings indicate that CYP2D6, CYP1A2 and, to a lesser extent CYP3A4, may have a role in protecting against Parkinson's disease induced by MPTP and other potential environmental neurotoxins.
|
8627546 |
1996 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, other hypotheses have been suggested: impairment of neuronal CYP 2D6 expression, transient modification of CYP 2D6 phenotype, or linkage of CYP2D6 gene to the candidate gene locus directly involved in IPD.
|
8726540 |
1996 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results provide evidence to suggest that there may be an unidentified locus for susceptibility to Parkinson's disease that is in linkage disequilibrium with dinucleotide repeat markers mapping near CYP2D6 on ch22q13.
|
9189044 |
1997 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We performed a case-control study to investigate the association of the poor metaboliser genotype of the cytochrome P450 2D6 gene with Parkinson's disease (PD).
|
9455978 |
1997 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of Parkinson's disease: a meta-analysis.
|
9918130 |
1998 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although some characteristic patterns of the combined genotypes were observed in both PD patients and controls, a strong association between the heterogeneity of the CYP2D6 gene and PD was not shown by combined genotype analysis.
|
9440484 |
1998 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data do not support the suggestion that the CYP2D6 gene is related to PD susceptibility in Chinese.
|
9667775 |
1998 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Impaired debrisoquine metabolism resulting from defects in the cytochrome P450 CYP2D6-debrisoquine hydroxylase gene has been shown to be associated with the development of Parkinson's disease (PD).
|
9613747 |
1998 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
By contrast with the common occurrence of polymorphism of the CYP2D6 gene (a gene involved with xenobiotic metabolism) in white people, it is very rare in China and is not thought to be a significant factor contributing to Parkinson's disease in Chinese people.
|
9810958 |
1998 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The CYP2D6 B mutation may be involved in pathogenesis of LBV and PD in a dominant-negative manner, or in the linkage disequilibrium of the CYP2D microsatellite to another pathogenic gene locus.
|
9633694 |
1998 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, reports of associations between alleles of the CYP2D6 locus (nearby on 22q13) and IPD, although inconsistent, indicated that an IPD susceptibility locus might be in strong linkage disequilibrium with CYP2D6.
|
9630632 |
1998 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
As yet, there is no conclusive evidence to suggest that CYP2D6 polymorphisms confer susceptibility to PD.
|
9539332 |
1998 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cytochrome P4502D6 (debrisoquine 4-hydroxylase) and Parkinson's disease in Chinese and Caucasians.
|
10210913 |
1999 |