Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.370 PosttranslationalModification disease BEFREE The list of ME candidates exhibited overlaps with recently identified human genes (including CYP2E1 and MGMT, where methylation has been associated with Parkinson disease and glioblastoma, respectively) in which perinatal DNA methylation levels where linked to maternal periconceptual nutrition. 23321599 2013
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.370 PosttranslationalModification disease BEFREE We found decreased methylation of the cytochrome P450 2E1 gene and increased expression of CYP2E1 messenger RNA in PD patients' brains, suggesting that epigenetic variants of this cytochrome contribute to PD susceptibility. 22238121 2012
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.370 GeneticVariation disease BEFREE Meanwhile, CYP2E1 rs2864987 was not associated with PD risk. 21360299 2011
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.370 Biomarker disease BEFREE In this study, the CYP2E1 gene was examined in a control population (n = 272) and a population with PD (n = 347), using a tag-single nucleotide polymorphism (tSNP) approach founded on HapMap Data. 19381774 2009
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.370 GeneticVariation disease BEFREE Genotype combinations characterized by the presence of two variant genotypes on their corresponding loci revealed that four combinations of GSTT1 null and MnSOD(-9Val) or GST null and MAOB-G or CYP2E1*5B and MAO-B-AG or CYP2E1*5B and DRD2 (Taq1A-het) genotypes in the patients exhibited severalfold higher and significant association with risk to PD. 18327668 2008
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.370 Biomarker disease CTD_human Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration. 16510128 2006
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.370 Biomarker disease BEFREE Our results suggest that CYP2E1 is not a major or independent determinant in the occurrence of PD in Taiwanese. 12454736 2002
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.370 Biomarker disease BEFREE Whether polymorphisms in other P450s (for example, CYP1A1 and CYP2E1) are implicated in PD remains to be established. 9539332 1998