Disease: Oestrogen deficiency ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.400 Biomarker disease BEFREE More recently, the role of estrogen in men was uncovered by prismatic examples of estrogen deficiency in male patients and by knockout of the estrogen receptor and aromatase in animals. 30566601 2019
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.400 Biomarker disease BEFREE In postmenopausal women, the neutral effect of aromatase inhibition is likely explained by pre-existing estrogen deficiency. 30920620 2019
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.400 GeneticVariation disease BEFREE For women with breast cancer, bone mineral density screening is recommended with long-term aromatase inhibitor use because of the risk of osteoporosis due to estrogen deficiency. 29794680 2018
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.400 GeneticVariation disease BEFREE For women with breast cancer, bone mineral density screening is recommended with long-term aromatase inhibitor use because of the risk of osteoporosis due to estrogen deficiency. 29794673 2018
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.400 Biomarker disease BEFREE Overall, our results strongly suggest that deregulation of miR-320a/RUNX2/CYP11A1 (CYP19A1) cascade plays an important role in the development of estrogen deficiency in human CCs. 27965096 2017
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.400 Biomarker disease BEFREE In contrast, male mice with estrogen deficiency showed same anti-depressive response to duloxetine treatments as aromatase transgenic mice. 29163055 2017
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.400 Biomarker disease BEFREE Further clinical studies seem acceptable and are needed to confirm the safety and efficacy of E4 for the breast in hormone replacement therapy, including hormone replacement therapy in women who have or have had BC, especially in those BC patients treated with aromatase inhibitors and suffering from serious complaints due to estrogen deficiency. 24997853 2014
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.400 Biomarker disease BEFREE Here we report that estrogen deficiency in mice caused by targeted disruption of the aromatase gene results in a significant inhibition of telomerase maintenance of telomeres in mouse ovaries in a tissue-specific manner. 21574023 2011
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.400 GermlineCausalMutation disease ORPHANET Aromatase deficiency owing to a functional variant in the placenta promoter and a novel missense mutation in the CYP19A1 gene. 21521281 2011
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.400 Biomarker disease BEFREE The generation of the aromatase knockout (ArKO) and estrogen receptor knockout (ERKO) mouse models has enabled researchers to characterize the effects of complete estrogen deficiency within the brain and hence behavior. 19401953 2009
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.400 GeneticVariation disease BEFREE A novel compound heterozygous mutation of the aromatase gene in an adult man: reinforced evidence on the relationship between congenital oestrogen deficiency, adiposity and the metabolic syndrome. 17547681 2007
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.400 GeneticVariation disease BEFREE Deleterious mutations in CYP19 can result in estrogen deficiency that will influence adult height to certain extent. 16733710 2006
CUI: C0853662
Disease: Oestrogen deficiency
Oestrogen deficiency 		0.400 Biomarker disease BEFREE One model of estrogen deficiency in rodents is the aromatase-knockout (ArKO) mouse. 15314222 2004