Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
By contrast, variation in the gene encoding the interleukin-23 (IL-23) receptor subunit, as well as in the IL12B, STAT3 and NKX2-3 gene regions, is associated with both Crohn's disease and ulcerative colitis.
|
18500230 |
2008 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.
|
18438405 |
2008 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.
|
18438405 |
2008 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.
|
18438405 |
2008 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease.
|
18438406 |
2008 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
An association between NKX2-3 and UC susceptibility was replicated and diverse evidence of epistasis in Japan was suggested.
|
19340882 |
2009 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
|
20228799 |
2010 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
NKX2-3 rs10883365 variant allele was associated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79).
|
21049557 |
2010 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the association of SNP rs10883365 located in the 5' flanking region of NKX2-3 with Japanese UC and colonic CD and determined the risk haplotype (haplotype B) for UC.
|
21514341 |
2011 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Consistent with epidemiologic predictions, many IBD-associated loci demonstrate genome-wide significant associations to both CD and UC, notably, genes whose products function in the interleukin-23 pathway, and transcription factors, including NK2 transcription factor related, locus 3 (NKX2-3), SMAD3, STAT3, ZMIZ1, and c-REL.
|
21530736 |
2011 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
A correlation with NKX2-3 and need for surgery (P = 0.038), and with HLA and steroid-responsiveness (P = 0.024) in UC patients was observed.
|
21818367 |
2011 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A positive correlation was observed between mRNA expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues from both CD and UC patients.
|
22377701 |
2012 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
NKX2-3 may play different roles in UC and CD pathogenesis by differential regulation of EGR1.
|
21968973 |
2012 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found 14 SNPs tagging 9 loci, including 21q21.1, NKX2-3, MST1, the HLA region, 1p36.13, IL10, JAK2, ORMDL3, and IL23R, to be associated with UC.
|
23974994 |
2013 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To generate large-scale evidence on whether NKX2-3 polymorphisms are associated with CD or UC susceptibility we have conducted a meta-analysis of 17 studies involving 17329 patients and 18029 controls.
|
24473197 |
2014 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk.
|
23942620 |
2014 |