Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
SNPs rs72553867 (IRGM gene), rs4409764 (NKX2-3 gene), and rs3731772 (AOX1 gene) increase the risk of pCD.
|
31844038 |
2019 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 × 10, odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 × 10, OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 × 10, OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 × 10, OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 × 10, OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 × 10, OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15.
|
25489960 |
2015 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To generate large-scale evidence on whether NKX2-3 polymorphisms are associated with CD or UC susceptibility we have conducted a meta-analysis of 17 studies involving 17329 patients and 18029 controls.
|
24473197 |
2014 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk.
|
23942620 |
2014 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
NKX2-3 may play different roles in UC and CD pathogenesis by differential regulation of EGR1.
|
21968973 |
2012 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A positive correlation was observed between mRNA expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues from both CD and UC patients.
|
22377701 |
2012 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found strong evidence of CD-association for 195 genes, identifying novel susceptibility genes (e.g., ISX, SLCO6A1, TMEM183A) as well as confirming many previously identified susceptibility genes in CD GWAS (e.g., IL23R, NOD2, CYLD, NKX2-3, IL12RB2, ATG16L1).
|
23071489 |
2012 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the pediatric cohort the associations of TNFSF15, NKX2-3 with CD, and PTGER4, NKX2-3, ZNF365, IFNG, PSMG1 with UC, were confirmed.
|
21818367 |
2011 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the association of SNP rs10883365 located in the 5' flanking region of NKX2-3 with Japanese UC and colonic CD and determined the risk haplotype (haplotype B) for UC.
|
21514341 |
2011 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Nkx2-3 gene variants are strongly associated with inflammatory bowel disease (IBD) and its expression is up-regulated in Crohn's disease (CD).
|
20188614 |
2010 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
NKX2-3 rs10883365 variant allele was associated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79).
|
21049557 |
2010 |
Crohn Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Nkx2-3 has been reported to be up-regulated in B cell lines and intestinal tissues from Crohn's disease patients and down-regulated in colorectal cancer.
|
20165982 |
2010 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients.
|
18936107 |
2009 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, no evidence of association with CD has been reported for the Crohn's disease susceptibility polymorphisms studied in the NKX2-3, ATG16L1, and IRGM genes.
|
19683022 |
2009 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease.
|
18438406 |
2008 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease.
|
18438406 |
2008 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.
|
18438405 |
2008 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
By contrast, variation in the gene encoding the interleukin-23 (IL-23) receptor subunit, as well as in the IL12B, STAT3 and NKX2-3 gene regions, is associated with both Crohn's disease and ulcerative colitis.
|
18500230 |
2008 |
Crohn Disease
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.
|
18438405 |
2008 |
Crohn Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
|
17554261 |
2007 |