Vitamin D Deficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy.
|
21145801 |
2011 |
Vitamin D Deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
VDDR-1A is a rare disorder which needs to be considered even in countries where nutritional vitamin D deficiency is still common.
|
27353739 |
2016 |
Vitamin D Deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Absence of a functional VDR or the key activating enzyme, 25-OHD-1alpha-hydroxylase (CYP27B1), in mice creates a bone and growth plate phenotype that mimics humans with the same congenital disease or severe vitamin D deficiency.
|
18694980 |
2008 |
Vitamin D Deficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, vitamin D deficiency in combination with the "AC" CYP27B1 genotype appeared to inhibit the CYP27B1 expression in NK cells (p=0.03).
|
23416105 |
2013 |
Vitamin D Deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the current study, vitamin D3 1α-Hydroxylase ["1α(OH)ase"] knockout mice were generated to mimic vitamin D deficiency <i>in vivo</i>.
|
28968988 |
2017 |
Vitamin D Deficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study plasma GH concentrations in pigs with inherited pseudo vitamin D deficiency type I (PDDR-I), which regularly show growth retardation, were compared during ontogeny with unaffected pigs of the same breed (German Landrace, DL) as control.
|
29762475 |
2018 |
Vitamin D Deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rescue of the pseudo-vitamin D deficiency rickets phenotype of CYP27B1-deficient mice by treatment with 1,25-dihydroxyvitamin D3: biochemical, histomorphometric, and biomechanical analyses.
|
12674324 |
2003 |
Vitamin D Deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
T1D-induced vitamin D deficiency is associated with impairments of renal and extrarenal CYP27B1 and VDR expression.
|
29552033 |
2018 |
Vitamin D Deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
The coexistence of vitamin-D-dependent-rickets type II with alopecia (VDDR IIA) and different forms of psychosis in the same inbred family has provided us with an opportunity to investigate the presumed relationship between vitamin D deficiency and psychosis.
|
14751420 |
2004 |
Vitamin D Deficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The demonstration that rare variants in CYP27B1, which encodes the enzyme that converts vitamin D to its active form, are strongly associated with MS risk supports a causal role of vitamin D deficiency as a risk factor for MS.
|
22547098 |
2012 |
Vitamin D Deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
The exact association between Vitamin D deficiency and chronic disease conditions remains unclear; however, studies have focused on the mechanism of Vitamin D regulation by assessing the role of the Vitamin D associated genes/proteins such as VDR (Vitamin D receptor), VDBP (Vitamin D Binding protein), CYP27B1 as these are integral parts of the Vitamin D signaling pathway.
|
31134092 |
2019 |
Vitamin D Deficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The gene expressions of vitamin D receptor and CYP27B1 and 25 hydroxyvitamin D plasma level ensured that the diets caused vitamin D deficiency or supplementation.
|
31175967 |
2019 |
Vitamin D Deficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results of the pilot case-control study indicated that both CT and TT genotypes of rs4646536 in CYP27B1 could increase the susceptibility of vitamin D deficiency when compared with CC genotype.
|
30993743 |
2019 |
Vitamin D Deficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
To our knowledge, this is the first to use 1-alpha-hydroxylase [1α(OH)ase] knockout mice which characterized vitamin D deficiency to establish the breast cancer bone metastases model.
|
28922720 |
2017 |