|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that loss of DAB2, a tumor suppressor, may enhance myosin VI-mediated transcription.
|
31744880 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Real time quantitative polymerase chain reaction (qRT-PCR) and Western blot analysis revealed that DAB2 was tumor repressor in PC cells, and its mRNA expression was negatively correlated with miR-93 in PC tissues.
|
30543885 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that Dab2 may function as a tumor suppressor in pancreatic cancer by modulation of the TGFβ-stimulated EMT and CSC phenotype.
|
31101868 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies reported that the tumor suppressor disabled-2 (DAB2) is a negative regulator of immune function.
|
30267088 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Disabled homolog 2 interactive protein functions as a tumor suppressor in osteosarcoma cells.
|
29963135 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Disabled-2 (Dab2) is known as a tumor suppressor as well as a Wnt pathway inhibitor.
|
30547821 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A scaffold protein DAB2 and its interaction partner DAB2IP have putative tumor suppressor gene (TSG) functions.
|
30477644 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study uses primary cultures of mouse ovarian surface epithelium (OSE) to demonstrate that one possible mechanism by which estrogen accelerates the initiation of ovarian cancer is by up-regulation of microRNA-378 via the ESR1 pathway to result in the down-regulation of a tumour suppressor called Disabled-2 (Dab2).
|
29196616 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our preliminary results showed that disabled homolog 2 interactive protein (DAB2IP), a putative tumor suppressor gene, is often downregulated in BCa with a radioresistant phenotype.
|
28586028 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Transforming growth factor-β (TGF-β) induces the expression of Disabled-2 (Dab2), an endocytic adaptor and tumour suppressor, concomitant with the induction of an epithelial-mesenchymal transition (EMT) in mammary epithelial cells.
|
27398911 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor cell proliferation, survival and migration are regulated by the deletion of ovarian carcinoma 2/disabled homolog 2 (DOC-2/DAB2) interacting protein (DAB2IP), a tumor suppressor that serves as a scaffold protein for H-Ras and TRAF2.
|
27036023 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results found patients with low-DAB2 expression ESCCs had significantly larger tumor size, deeper tumor invasion depth, lymph node metastasis, worse survival, and higher recurrence rate (P<0.05).
|
27036032 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Human Disabled-2 (DAB2) was reported to act as a tumor suppressor gene and was found downregulated in numerous cancer types.
|
25719979 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, DAB2 has always been regarded as a tumor suppressor gene.
|
26143155 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The disabled homolog 2 (DAB2) gene was recently identified as a tumor suppressor gene with its expression downregulated in multiple cancer types.
|
24037530 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MiR187 downregulated tumor suppressor gene disabled homolog-2 (Dab2), decreased the interaction of Dab2 with adapter protein Grb2, resulting in Ras activation, phosphorylation/activation of extracellular signal-regulated kinase (ERK) and AKT, and subsequent stabilization of MYC oncoprotein.
|
24104394 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Disabled-2 (Dab2) is considered a tumor suppressor and is downregulated in cancers.
|
24002585 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
During the later stages, however, continued increased levels of miR-187 inhibits the Dab2-dependent EMT that is associated with tumor invasiveness, which is presumed to be the reason why cancers with high miR-187 levels were associated with better survivals.
|
21725366 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Human Disabled-2 (Dab2), a putative tumor suppressor gene, is frequently down-regulated in human tumors.
|
23005040 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data indicate that DAB2 acts as a tumor suppressor by dictating tumor cell TGF-beta responses, identify a biomarker for SCC progression, and suggest a means to stratify patients with advanced SCC who may benefit clinically from anti-TGF-beta therapies.
|
20592473 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We aimed to investigate the possible tumour suppressor effect of DAB2 in nasopharyngeal carcinoma (NPC).
|
20525238 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
FTEb luteal and SerCa samples expressed higher levels of oncogenic SKIL and decreased levels of tumor suppressor DAB2, relative to FTEb follicular samples.
|
18593983 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor-prone phenotype of dab2(+/-) mice provides additional support for a role of human Dab2 as a tumor suppressor, and the sex-biased embryonic lethality suggests a genetic interaction between p53 and dab2 genes in female mice.
|
16816378 |
2006 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To determine whether promoter hypermethylation contributes to loss of DAB2 expression in ESCCs, methylation status of DAB2 promoter was analyzed in DAB2 immuno-negative tumors using methylation-specific PCR.
|
17009406 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
DAB2 mRNA was expressed in all non-neoplastic and all tumor specimens, while Midkine mRNA was detected in 8/11 non-neoplastic specimens versus 11/13 tumors.
|
15754000 |
2005 |