|
Nasopharyngeal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Accordingly, it was concluded that miR-200c exerted a tumor-promoting role in NPC development by targeting DACH1, which may contribute to the increase in the rates of NPC proliferation and migration. miR-200c may be a potential diagnostic and prognostic biomarker for NPC.
|
30431444 |
2019 |
|
Female Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study we found that DACH1 was expressed less in MBC and HER2 was expressed more in FBC.
|
29478945 |
2018 |
|
Small cell carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, 186 upregulated (e.g., GSR, HCP5) and 144 downregulated DEGs (e.g., MET, GRM8, and DACH1) were identified between the SCLC patients with lymph node metastasis and without lymph node metastasis.
|
30364292 |
2018 |
|
Malignant neoplasm of female breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study we found that DACH1 was expressed less in MBC and HER2 was expressed more in FBC.
|
29478945 |
2018 |
|
Carcinoma of Male Breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study we found that DACH1 was expressed less in MBC and HER2 was expressed more in FBC.
|
29478945 |
2018 |
|
Malignant neoplasm of male breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study we found that DACH1 was expressed less in MBC and HER2 was expressed more in FBC.
|
29478945 |
2018 |
|
Laryngeal Squamous Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
DACH1 may act as a tumor suppressor gene and could be a potential target for therapeutic intervention of LSCC.
|
30261897 |
2018 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Body mass index (P = .023) and DACH1 (P = .034) were correlated with MBC prognosis, whereas the expression of AR (P = .049), SIX1 (P = .048), surgery (P < .001), and chemotherapy (P = .001) were important for FBC in addition to already known factors: tumor size and location, TNM stage (lymph nodes and organ metastasis), radiotherapy, and ER and human epidermalgrowth factor receptor-2 (HER2) expression.
|
29478945 |
2018 |
|
Pancreatic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of DACH1 activity by short hairpin RNA represses cell proliferation and tumor invasion in pancreatic cancer.
|
27278537 |
2016 |
|
Malignant neoplasm of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of DACH1 activity by short hairpin RNA represses cell proliferation and tumor invasion in pancreatic cancer.
|
27278537 |
2016 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
We recruited obese individuals receiving a dietary intervention according DACH (German, Austrian, and Swiss Society of Nutrition) reference values and guidelines for 'prevention and therapy of obesity' of DAG e.V., DDG, DGE e.V., and DGEM e.V. over three months.
|
25609655 |
2015 |
|
Oral Cavity Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The analysis of oral carcinoma cell lines showed very frequent methylation of SFRP2 and WIF-1 and also a less frequent methylation of DACH1 and DKK1.
|
25487617 |
2015 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The analysis of oral carcinoma cell lines showed very frequent methylation of SFRP2 and WIF-1 and also a less frequent methylation of DACH1 and DKK1.
|
25487617 |
2015 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
However, DACH1 expression was absent in some carcinomas, most of which were DNA mismatch-repair deficient.
|
24472434 |
2014 |
|
Cardiovascular Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The T allele of rs1408888 of DACH1 was associated with YOD, prediabetes and CVD in Chinese.
|
24465431 |
2014 |
|
Esophageal Neoplasms
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
We found that DACH1 expression was regulated by promoter region hypermethylation in esophageal cancer cell lines.
|
24743895 |
2014 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DACH1 expression inhibited epithelial-mesenchymal transition and metastasis by inhibiting transforming growth factor (TGF)-β signalling and suppressed GC cell proliferation through inducing G2/M phase arrest.
|
24912879 |
2014 |
|
Esophageal carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
We found that DACH1 expression was regulated by promoter region hypermethylation in esophageal cancer cell lines.
|
24743895 |
2014 |
|
Prediabetes syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The T allele of rs1408888 of DACH1 was associated with YOD, prediabetes and CVD in Chinese.
|
24465431 |
2014 |
|
Malignant neoplasm of esophagus
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
We found that DACH1 expression was regulated by promoter region hypermethylation in esophageal cancer cell lines.
|
24743895 |
2014 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DACH1 expression inhibited epithelial-mesenchymal transition and metastasis by inhibiting transforming growth factor (TGF)-β signalling and suppressed GC cell proliferation through inducing G2/M phase arrest.
|
24912879 |
2014 |
|
Breast cancer, lobular
|
0.010 |
Biomarker
|
disease |
BEFREE |
Strong nuclear DACH1 staining is more prevalent in tubular and lobular breast cancer.
|
24392136 |
2014 |
|
Malignant neoplasm of endometrium
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Loss of DACH1 expression was found in breast, prostate, and endometrial cancer.
|
24149323 |
2013 |
|
Renal Cell Dysplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we present a patient with renal dysplasia carrying homozygous missense mutations in both BMP4 (p.N150K) and DACH1 (p.R684C).
|
23262432 |
2013 |
|
Otofaciocervical Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our results show that the strategy of pooling DNA is a powerful, cost-effective application for WES in consanguineous families and establish PAX1 as a new disease-causing gene for OFCS and as part of the EYA-DACH-SIX-PAX network, important in early embryogenesis.
|
23851939 |
2013 |