Azoospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
From these, sperm from 40 randomly selected men with no DAZ microdeletions in their leukocytes (n = 10 oligozoospermia; n = 10 asthenozoospermia; n = 10 oligoasthenozoospermia; and n = 10 near-azoospermia) were were compared to sperm from men of normal semen quality (n = 10) using combined primed in situ labelling and fluorescent in situ hybridization (PRINS-FISH) technique as well as screening for sex chromosome aneuploidy.
|
28521575 |
2018 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of partial azoospermia factor c deletion and DAZ copy number in azoospermia and severe oligozoospermia.
|
27739146 |
2016 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In men with AZFc subdeltions, loss of two DAZ and one CDY1 gene copy made them highly susceptible to azoospermia and severe oligozoospermia with OR of 29.7 and 26, respectively.
|
26149076 |
2015 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
More interestingly, partial DAZ1/2 deletion was associated with azoospermia (ORs=2.63, 95%CI: 1.19-5.81, I(2)=64.7%) and oligozoospermia (ORs=2.53, 95%CI: 1.40-4.57, I(2)=51.8%), but partial DAZ3/4 deletion was not associated with azoospermia (ORs=0.71, 95%CI: 0.23-2.22, I(2)=71.7%,) and oligozoospermia (ORs=1.21, 95%CI: 0.65-2.24, I(2)=55.5%).
|
26232607 |
2015 |
Azoospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
The AZFc(azoospermia factor c)/DAZ (deleted in azoospermia) duplications might underlie the susceptibility of Y-hg K* to spermatogenic impairment.
|
23696539 |
2013 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
gr/gr deletions were analyzed by using markers sY1291, sY1191 and sY1197 and by investigating the presence of single nucleotide variants (SNV) in DAZ and CDY1 genes in patients with azoospermia (n = 44), cryptozoospermia (n = 51) or severe oligozoospermia (n = 92).
|
18326516 |
2008 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Copy deletion screening of DAZ gene family on the Y chromosome in 485 patients with idiopathic azoospermia or oligozoospermia and 236 fertile men revealed that the prevalence of deletion patterns of the entire DAZ gene and DAZ1/DAZ2 gene were significantly higher in the patients than in fertile men.
|
16580401 |
2006 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We conclude that partial deletions of the DAZ genes are associated with oligozoospermia but not with azoospermia; however, an increased number of DAZ genes does not seem to be a statistically significant risk factor for spermatogenic failure.
|
16275261 |
2005 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Deletions in the DAZ (deleted in azoospermia) loci sgamma254 and sgamma255 were found in three patients with idiopathic azoospermia, resulting in an estimated frequency of deletions of 10.7% in idiopathic azoospermia men.
|
12085101 |
2002 |
Azoospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Deletion of RBM and DAZ in azoospermia: evaluation by PRINS.
|
11807882 |
2002 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Twelve of 101 patients (12%) with the AZFc/DAZ microdeletion were found, including 8 with azoospermia (11%) and 4 with severe oligozoospermia (14.3%), and 1 patient had a AZFb and AZFc/DAZ double deletion.
|
11930664 |
2002 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Such deletions determine azoospermia more frequently than severe oligozoospermia and involve especially the AZFc region including the DAZ gene family.
|
11294825 |
2001 |
Azoospermia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
To investigate the expression of deleted in azoospermia (DAZ), RNA-binding motif (RBM), and chromodomain y1 (CDY1) genes in the testes of men with azoospermia with variable histopathologies.
|
11163833 |
2001 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Blood, spermatozoa or testicular cells from 47 men (27 oligozoospermia, 20 azoospermia), including six Y-deleted patients, were screened for mosaicism using double target fluorescence in-situ hybridization (FISH) with Y centromeric and deleted in azoospermia (DAZ) gene-specific probes.
|
10908277 |
2000 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The DAZ (Deleted in AZoospermia) gene family was isolated from a region of the human Y chromosome long arm that is deleted in about 10% of infertile men with idiopathic azoospermia.
|
10819768 |
2000 |
Azoospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
DNA screening tests for DAZ genes before ICSI may help in the genetic counseling of patients with idiopathic azoospermia or severe oligozoospermia.
|
10360905 |
1999 |
Azoospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
These data, although highly suggestive, do not constitute formal proof that DAZ actually plays a role in azoospermia, as no small intragenic deletions, rearrangements or point mutations in the gene have been found.
|
9239708 |
1997 |
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The DAZLA (DAZ Like Autosomal) gene on human chromosome 3 shares a high degree of homology with the DAZ (Deleted in AZoospermia) gene family on the Y chromosome, a gene family frequently deleted in males with azoospermia or severe oligospermia.
|
9294855 |
1997 |
Azoospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Screening for deletions of the Y chromosome involving the DAZ (Deleted in AZoospermia) gene in azoospermia and severe oligozoospermia.
|
9091344 |
1997 |
Azoospermia
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|