DAZ1, deleted in azoospermia 1, 1617

N. diseases: 23; N. variants: 0
Disease: Male infertility ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 Biomarker phenotype BEFREE High frequency of de novo DAZ microdeletion in sperm nuclei of subfertile men: possible involvement of genome instability in idiopathic male infertility. 28521575 2018
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 GeneticVariation phenotype BEFREE The purpose of this study was to determine the association of AZFc subdeletions (gr/gr, b1/b3 and b2/b3) and deletion of DAZ and CDY1 gene copies with male infertility 26149076 2015
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 GeneticVariation phenotype BEFREE In our meta-analysis, partial DAZ1/2 deletion is a risk factor for male infertility and different ethnicities have different influences, whereas partial DAZ3/4 deletion has no effect on fertility but partial DAZ3/4 deletion might have an impact on Non-East Asian male. 26232607 2015
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 GeneticVariation phenotype BEFREE Analysis of DAZ gene copies in Tunisian population, suggested that the simultaneous deletion of DAZ2 and DAZ4 gene copies is associated with male infertility, and that oligospermia seems to be promoted by removing DAZ4 copy. 24878370 2014
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 GeneticVariation phenotype BEFREE Analysis of DAZ gene copies in AZFc microdeletions suggests that the contribution of the different deletions to male infertility varies. 23512232 2013
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 GeneticVariation phenotype BEFREE Together with published data, our analysis of DAZ gene copy suggested that the contribution of the different deletions to male infertility varies: only partial AZFc deletions removing DAZ1/DAZ2 seem to be associated with spermatogenic impairment, whereas those removing DAZ3/DAZ4 may have no or little effect on fertility. 15744033 2005
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 GeneticVariation phenotype BEFREE Deletions of the AZFc region in Yq11.2, which include the DAZ gene family, are responsible for most cases of male infertility and were associated with severe oligozoospermia and also with a variable testicular pathology. 15347736 2004
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 Biomarker phenotype LHGDN Our findings suggest that the loss of only some copies of DAZ is sufficient to lead to severe male infertility, but it is not a frequent finding in cryptorchid men. 15066457 2004
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 Biomarker phenotype BEFREE Our findings suggest that the loss of only some copies of DAZ is sufficient to lead to severe male infertility, but it is not a frequent finding in cryptorchid men. 15066457 2004
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 Biomarker phenotype BEFREE The deleted-in-azoospermia (DAZ) gene family constitutes the major candidate for the AZFc (azoospermia factor c) phenotype of male infertility, being deleted in about 10% of azoospermic and severely oligozoospermic subjects. 11883873 2002
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 GeneticVariation phenotype BEFREE Microdeletion on the Y chromosome, especially at its AZFc/DAZ regions, may be a major cause of azoospermia and severe oligozoospermia leading to male infertility in China. 11930664 2002
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 Biomarker phenotype LHGDN [Microdeletion of chromosome Y in male infertility: role of the DAZ gene]. 11688365 2002
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 Biomarker phenotype BEFREE The DAZ (deleted in azoospermia) gene family on the Y chromosome long arm is the major candidate for the AZFc (azoospermia factor c) phenotype of male infertility and it is expressed only in germ cells. 12039700 2002
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 GeneticVariation phenotype BEFREE The DAZ (deleted in azoospermia) gene family is considered the major AZFc ("azoospermia factor" c) candidate responsible for male infertility. 11263480 2001
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 GeneticVariation phenotype BEFREE Deletions of the DAZ (deleted in azoospermia) gene family are frequently responsible for male infertility and are generally assessed by analyses of genomic DNA extracted from peripheral leukocytes. 10469697 1999
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 Biomarker phenotype BEFREE The DAZ (Deleted in AZoospermia) and DAZLA (DAZ-like autosomal) genes may be determinants of male infertility. 8968756 1996
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 Biomarker phenotype BEFREE The presence of deletions that do not overlap with the DAZ region suggests that genes other than the DAZ gene may also be implicated in the pathogenesis of some subsets of male infertility. 8636331 1996
CUI: C0021364
Disease: Male infertility
Male infertility 		0.200 Biomarker phenotype HPO