DBH, dopamine beta-hydroxylase, 1621

N. diseases: 202; N. variants: 26
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 AlteredExpression group BEFREE The aim of the present study was to evaluate the effects of zamicastat, a novel DβH inhibitor that decreases noradrenaline and increases dopamine levels in peripheral sympathetically innervated tissues, on the hemodynamic and cardiometabolic parameters in salt-induced hypertension and heart failure in the Dahl salt-sensitive (SS) rat. 30401628 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker group BEFREE The purpose of this study was to investigate immunoreactivity for dopamine β-hydroxylase (DBH) and tyrosine hydroxylase (TH) in carotid body (CB) glomus cells in spontaneously hypertensive rats (SHR/Izm) at 4 (prehypertensive stage), 8 (early stage of developmental hypertension), 12 (later stage of developmental hypertension), and 16weeks of age (established hypertensive stage). 28473232 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker group BEFREE Etamicastat is a dopamine β-hydroxylase (DβH) inhibitor currently in clinical development for the treatment of hypertension and heart failure. 24296323 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker group RGD Continuous antagonism of the ghrelin receptor results in early induction of salt-sensitive hypertension. 20596792 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 GeneticVariation group BEFREE Consequently, we found a significant interaction between the DBH -1021C/T polymorphism and fasting plasma glucose (FPG) in the association with hypertension. 16097364 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 GeneticVariation group LHGDN Consequently, we found a significant interaction between the DBH -1021C/T polymorphism and fasting plasma glucose (FPG) in the association with hypertension. 16097364 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 AlteredExpression group BEFREE There was no significant difference in serum DBH activity between normal subjects and individuals with hypertension in any age group. tfurthermore, there was no significant correlation of mean blood pressure with serum DBH activity with or without correction of DBH for age differences; Highly significant correlations of serum DBH activity were found in sibling-sibling pairs and in mean parent-child pairs. 1120928 1975