DBH, dopamine beta-hydroxylase, 1621

N. diseases: 202; N. variants: 26
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 Biomarker disease BEFREE Pharmacogenetics of Dopamine β-Hydroxylase in cocaine dependence therapy with doxazosin. 29498170 2019
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 Biomarker disease BEFREE Disulfiram (Antabuse), an acetaldehyde dehydrogenase and dopamine-beta hydroxylase inhibitor, has shown promise in preclinical and clinical studies as a pharmacotherapy for cocaine addiction. 29963872 2018
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 Biomarker disease PSYGENET Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment. 24462581 2014
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 Biomarker disease PSYGENET The influence of dopamine β-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study. 24809448 2014
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 GeneticVariation disease BEFREE The influence of dopamine β-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study. 24809448 2014
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 Biomarker disease PSYGENET This study indicates that the DBH genotype of a patient could be used to identify a subset of individuals for which disulfiram treatment might be an effective pharmacotherapy for cocaine dependence. 22906516 2013
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 Biomarker disease PSYGENET DBH gene as predictor of response in a cocaine vaccine clinical trial. 23458673 2013
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 Biomarker disease BEFREE Disulfiram is a cocaine addiction pharmacotherapy that inhibits dopamine β-hydroxylase (DβH) and reduces norepinephrine production. 23849431 2013
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 GeneticVariation disease BEFREE This study indicates that a patient's DBH genotype could be used to identify a subset of individuals for whom vaccine treatment may be an effective pharmacotherapy for cocaine dependence. 23458673 2013
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 GeneticVariation disease BEFREE This study indicates that the DBH genotype of a patient could be used to identify a subset of individuals for which disulfiram treatment might be an effective pharmacotherapy for cocaine dependence. 22906516 2013
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 Biomarker disease PSYGENET Pharmacogenetic randomized trial for cocaine abuse: disulfiram and α1A-adrenoceptor gene variation. 23849431 2013
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 Biomarker disease BEFREE Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. 20801583 2010
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 GeneticVariation disease BEFREE We genotyped the Int8 and 3'UTR variable number of tandem repeats of the dopamine transporter gene (DAT1/SLC6A3), the TaqIA (rs1800497) and TaqIB (rs1079597) SNP polymorphisms within the dopamine receptor D2 gene and the 19-bp insertion/deletion and c.444G>A (rs1108580) polymorphisms of the dopamine β-hydroxylase gene (DBH) in a Spanish sample of 169 patients with cocaine addiction and 169 sex-matched controls. 20505554 2010
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 GeneticVariation disease BEFREE Disulfiram and methylphenidate pharmacotherapies for cocaine addiction are optimized by considering polymorphisms affecting DbetaH and DAT1 respectively. 19462300 2009