Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present investigation, an association between the -240A allele and a reduced risk for MDD was observed, but the genotype distributions of controls were only just in marginal agreement with Hardy-Weinberg equilibrium.The T-T haplotype in the ACE gene was significantly associated with an increased risk for MDD.
|
19713413 |
2009 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Influence of a functional polymorphism within the angiotensin I-converting enzyme gene on partial sleep deprivation in patients with major depression.
|
12633893 |
2003 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysing the data for both genes we found that the combined actions of ACE and Gbeta3 genotypes accumulate in carriers of the ACE D allele (ID and DD) and Gbeta3 TT homozygotes with ID/DD-TT carriers showing a more than five-fold increase in risk for major depression (crude OR = 5.83, 95% CI 1.99-17.08, P = 0.0002).
|
12476328 |
2002 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
When individuals with major depression on at least one occasion were analyzed, a significant association (OR: 2.14 [95% CI: 1.13-4.20], z = 2.28, p = 0.02), remaining after exclusion of dementia, with rs1799752 in ACE was found.
|
27639288 |
2017 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the screening sample, two SNPs within the ACE gene were significantly associated with unipolar major depression.
|
16924268 |
2006 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results demonstrate that these ACE variants did not play a major role in the clinical manifestations or antidepressant response for our MDD patients.
|
12203048 |
2002 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined the frequency of a functional insertion/deletion (I/D) polymorphism in the 16th intron of the ACE gene (located on chromosome 17q23) in groups of patients with schizophrenia (n = 104 and 113), major depression (n = 55), and bipolar disorder (n = 87) compared to healthy control subjects (n = 87).
|
11920854 |
2002 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to examine the role of I/D polymorphism of ACE gene in MDD risk and its treatment response by a case-control study and meta-analysis.
|
22036796 |
2012 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Association of angiotensin-converting enzyme (ACE) gene polymorphism with elevated serum ACE activity and major depression in an Iranian population.
|
22688325 |
2012 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The results of the present study suggest that aberrations in ACE promoter DNA methylation may be an underlying cause of MD and probably a common pathogenic factor for the bi-directional relationship between MD and cardiovascular disorders.
|
22808171 |
2012 |
Major Depressive Disorder
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
The results of the present study suggest that aberrations in ACE promoter DNA methylation may be an underlying cause of MD and probably a common pathogenic factor for the bi-directional relationship between MD and cardiovascular disorders.
|
22808171 |
2012 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, this study supports the hypothesis of RAS overactivity in depression in that the genotype associated with higher serum ACE activity in an Iranian population was also associated with MDD.
|
22688325 |
2012 |