Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Several studies have demonstrated that the deletion polymorphism in the angiotensin-I-converting enzyme acts as a risk factor for cardiovascular disease in diabetic patients.
|
8989728 |
1996 |
Cardiovascular Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The increased bradykinin levels with a concomitant decrease of plasma ACE activity by HRT in hypertensive PMW seem to be beneficial for reducing the risk of CVD.
|
10560792 |
1999 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Several polymorphisms of genes encoding for components of the renin angiotensin system such as the M235T polymorphism in the angiotensinogen gene, the 287-base-pair insertion (I)/deletion (D) polymorphism at intron 16 of the ACE gene, and the A1166C polymorphism in the angiotensin II type 1 receptor gene have been associated with an increased risk of cardiovascular diseases.
|
10351920 |
1999 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In children with type 1 diabetes, the role of ACE polymorphism as a probable contributor to CVD seems to be partially mediated through other factors such as poor glycemic control, TC, and Lp(a) level.
|
15189494 |
2004 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Angiotensin-converting enzyme inhibitors (ACEIs) have been used in the treatment of various cardiovascular diseases.
|
16144506 |
2005 |
Cardiovascular Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Flavonoids diminish the risk of cardiovascular diseases and the flavonoid taxifolin normalizes the activity of ACE.
|
30148999 |
2018 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The author summarizes a brief analysis of associated cardiovascular disease and nutritional consequences, exploring the controversial cause-effect on mortality and technique failure.Therapeutic modalities aiming to reduce PPL (angiotensin-converting enzyme inhibitors [ACEI]s and vitamin D therapies) were explored, although it is unclear whether PPL represents a valid therapeutic target or, on the other hand, is solely a manifestation of endothelial dysfunction.
|
31088933 |
2020 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Taken together, the results of this study are compatible with the proposition that the ACE polymorphism is associated with cardiovascular disease partially mediated through the four disorders in our population.
|
11071385 |
2000 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In this system, the Angiotensin Converting Enzyme (ACE) is one of the key regulators and has been studied in relation to cardiovascular disease and mortality.
|
16008546 |
2005 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The human angiotensin converting enzyme (ACE) gene is a candidate genetic locus for stroke because of the importance of the renin-angiotensin system to the development of cardiovascular disease.
|
8903617 |
1995 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Angiotensin-converting enzyme (ACE) inhibitors (ACEI) are widely used in the management of cardiovascular diseases but with significant interindividual variability in the patient's response.
|
28587581 |
2017 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The renin-angiotensin system blockers (RASBs), including angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs), are widely used to reduce cardiovascular disease (CVD) events.
|
28387887 |
2017 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Angiotensin-converting enzyme DD genotype and cardiovascular disease in heterozygous familial hypercholesterolemia.
|
9603531 |
1998 |
Cardiovascular Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The HD patients, particularly those with CVD, showed a significant increase in the levels of ACE and Ang II, whereas ACE2 and Ang-(1-7) levels were lower than those in the healthy controls.
|
29157100 |
2017 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The angiotensin I-converting enzyme gene is one of the major genes of the renin-angiotensin and kallikrein-kinin systems and is a candidate gene for several cardiovascular diseases for which a genetic predisposition has been established.
|
7850408 |
1994 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Inhibition of the angiotensin-converting enzyme (ACE) protects against the progression of several cardiovascular diseases.
|
15772297 |
2005 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Following the discovery of a functional variation in the angiotensin-converting enzyme gene, research has identified other genetic variations in the renin-angiotensin system that may contribute to cardiovascular disorders.
|
9717050 |
1998 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Angiotensin-converting enzyme (ACE) is a vital enzyme in the renin-angiotensin-aldosterone system, and there are reports in the literature describing its role in the development of cardiovascular system diseases, with I/D polymorphism of the ACE gene.
|
20449805 |
2010 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The angiotensin-converting enzyme (ACE) deletion allele, ACE D, is associated with increased cardiac ACE activity, cardiac fibrosis, and adverse outcomes in cardiovascular disease and has been linked with failure of antiatrial fibrillation (anti-AF) drug treatment.
|
23876437 |
2013 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The ACE rs4291 TT genotype, which has been associated with HPA axis hyperactivity and higher levels of serum angiotensin converting enzyme (ACE), predicted acute stress response and reports of physician-diagnosed CVD in a national sample following collective stress.
|
23055331 |
2012 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The aim of this study is to assess the association of two polymorphisms, the cartilage intermediate layer protein 2 (CILP2) G/T and angiotensin converting enzyme (ACE) I/D, with blood pressure and anthropometrical and biochemical parameters related to the development of cardiovascular disease.
|
24350279 |
2013 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A polymorphism of the angiotensin I converting enzyme (ACE) gene has recently been reported and analysis of this polymorphism has indicated that it is associated with several cardiovascular diseases.
|
7734106 |
1995 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Therapies targeting these RAS components, such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers, are commonly used for treatment of hypertension and cardiovascular diseases, with blood pressure-lowering effects attributed in part to sympathetic inhibition and parasympathetic facilitation.
|
30413906 |
2019 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The insertion/deletion (ID) polymorphism of the ACE gene defined by the presence or absence of the 287 base pair Alu sequence situated in intron 16 has been investigated as a possible genetic marker for a variety of cardiovascular disease including myocardial infarction, essential hypertension, cardiomyopathy, and diabetic vascular complications.
|
8743524 |
1996 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
<b>Abbreviations</b>: Angiotensin-converting enzyme (ACE); Angiotensin converting enzyme inhibitors (ACEIs); Angiotensin II (ANG II); Analysis of variance (ANOVA); Angiotensin receptor blockers (ARBs); Blood Pressure (BP); Calcium Antagonists Calcium Channel Blockers (CCB); Chronic kidney diseases (CKD); Sodium carboxyl methyl cellulose (CMC-Na); Cardiac mass index (CMI); Cardiovascular diseases (CVD); Diastolic blood pressure (DBP); Enzyme-linked immunosorbent assay (ELISA); Hematoxylin-eosin (H&E); Kidney mass index (KMI); Liver mass index (LMI); Mean arterial blood pressure (MAP); Plasma renin concentration (PRC); Renin-angiotensin system (RAS); Rennin (REN); Systolic blood pressure (SBP); Student-Newman-Keuls q test (SNK-q test); Spontaneous hypertension rats (SHR); Valsartan asleep Administration (VSA); Valsartan awake Administration (VWA); Wistar-Kyoto (WKY); Mesor (M); Amplitude (A); Phase (φ).
|
31096810 |
2019 |