Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We conclude that in subjects attending a metabolic ward, homozygosity for a deletion polymorphism of the ACE gene consistently discriminates subjects with a stroke history.
|
8620347 |
1996 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The preliminary results of the present study failed to confirm our hypothesis that ACE gene polymorphism is a cardiovascular risk factor in children of parents with premature stroke.
|
10653133 |
2000 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We conclude that determination of the carotid IMT and of the ACE I/D polymorphism do not permit discrimination of the cardiovascular risk in children of parents with or without premature stroke.
|
15858957 |
2005 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
ACE-inhibitor users with at least one copy of the 235T-allele of the AGT gene might have an increased risk of MI and stroke.
|
17299437 |
2007 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Many patients who receive intravenous (i.v.) recombinant tissue-plasminogen activator (rt-PA) for acute cerebral ischemia were under angiotensin-converting enzyme inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs) at stroke onset.
|
29549467 |
2018 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
DD genotype of the angiotensin-converting enzyme gene and stroke in Slovenian population.
|
10653135 |
2000 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The frequencies of the different genotypes for the Leiden V mutation and ACE I/D polymorphism in the 3 subgroups of stroke were compared with 199 stroke-free control subjects whose MRI findings were normal.
|
11596779 |
2001 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Twelve of 16 studies found that ADD1 polymorphism alone or in combination with that of ACE positively associates with stroke or coronary heart disease or renal or vascular dysfunctions.
|
15699449 |
2005 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
These findings offer insight into ACE expression and activity in response to stroke, and further our understanding of ACE mechanisms.
|
29228591 |
2017 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
In regard to clinical studies, treatment with Angiotensin Converting Enzyme (ACE) inhibitors and AT1 receptor antagonists exerts preventive and therapeutic effects on stroke.
|
31849284 |
2019 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Angiotensin-converting enzyme (ACE) polymorphism may play a role in stroke and silent brain infarction (SBI) susceptibility, but the results among the populations studied to date have not been consistent.
|
17922891 |
2008 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
There was no significant association between ACE genotype and the stroke subgroups investigated.
|
8903617 |
1995 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Randomized, active controlled parallel group trials were included if they compared CCBs with α-blockers, β-blockers, angiotensin II receptor blockers, angiotensin-converting enzyme inhibitors, or diuretics, had a follow-up of ≥6 months, and had assessments of blood pressure (BP) and CV events [all-cause death, CV death, major CV events (myocardial infarction, MI; congestive heart failure, CHF; stroke; and CV death), MI, stroke, or CHF] in patients with baseline systolic/diastolic BP ≥140/≥90 mm Hg with either concomitant previous stroke and/or CAD.
|
26588586 |
2017 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
This lack of association between stroke and ACE I/D polymorphism did not change in the presence of traditional risk factors (hypertension, diabetes mellitus, smoking, and dyslipidemia).
|
19596363 |
2009 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We observed that ACE ID/DD genotypes are associated with an elevated incidence of stroke in a South Indian population from Andhra Pradesh.
|
18586276 |
2008 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Prior stroke/TIA and/or PAD patients were less likely to receive evidence-based medical therapies (dual antiplatelet therapy: stroke/TIA= 88.6%, PAD= 86.6%, stroke/TIA+PAD= 85.7%, none= 92.2%, p<0.001; β-blockers: stroke/TIA= 77.1%, PAD= 72.1%, stroke/TIA+PAD= 71.9%, none= 80.8%, p<0.001; angiotensin-converting enzyme inhibitors/angiotensin receptor blockers: stroke/TIA= 86.3%, PAD= 83.6%, stroke/TIA+PAD= 83.2%, none= 87.1%, p=0.030) and to undergo percutaneous revascularization (stroke/TIA= 52.8%, PAD= 45.6%, stroke/TIA+PAD= 43.7%, none= 67.9%, p<0.001), despite more extensive coronary artery disease (three-vessel disease: stroke/TIA= 29.1%, PAD= 38.3%, stroke/TIA+PAD= 38.3%, none= 20.2%, p<0.001).
|
28627932 |
2018 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Individuals harboring DD genotype of ACE I/D polymorphism are more predisposed to hemorrhagic stroke than ischemic stroke.
|
25015258 |
2015 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The authors conducted a population-based, case-control study at Group Health (Seattle, Washington) between 1995 and 1999 to determine whether common haplotypes in the angiotensinogen gene (AGT), the renin gene, the angiotensin-converting enzyme gene, and the angiotensin II receptor type 1 and receptor type 2 genes were associated with the risk of myocardial infarction and stroke among pharmacologically treated hypertensive patients.
|
17522061 |
2007 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The deletion polymorphism in the angiotensin-converting enzyme gene is a new independent risk factor for lacunar stroke but is not a risk factor for stroke associated with carotid stenosis.
|
7631331 |
1995 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We investigated the association between ACE genotype and the incidence of stroke in a large, prospective, matched case-control sample from the Physicians' Health Study.
|
9918518 |
1999 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Amlodipine therapy was associated with 25% higher risk of heart failure (relative risk [RR]: 1.25, 95% confidence interval [CI], 1.05-1.49, P = .019) but 17% lower risk of stroke (RR: 0.83, [95% CI, 0.72-0.97], P = .009) without statistically significant effect on acute myocardial infarction (AMI) compared to major alternative antihypertensive therapy (MAAT), including β-blocker, diuretic, angiotensin-converting enzyme inhibitor, or angiotensin-receptor blocker.
|
29739234 |
2018 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Inhibitors of ACE and antagonists of the AT1R are used in the treatment of hypertension, myocardial infarction, and stroke.
|
19706421 |
2009 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
CTD_human |
Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls.
|
15534175 |
2004 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The ACE genotype was not associated with the long-term risks of stroke, cardiac events, mortality, dementia, or cognitive decline; neither did the ACE genotype predict the blood pressure reduction associated with the use of the ACE inhibitor perindopril.
|
12925557 |
2003 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to evaluate whether the ACE I/D genotype is associated with stenosis of extracranial arteries and stroke in middle-aged and aged men and women.
|
9733227 |
1998 |