ACE, angiotensin I converting enzyme, 1636

N. diseases: 101; N. variants: 18
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 Biomarker disease PSYGENET As SZ and BD have some susceptibility genes in common and since unaffected first-degree relatives of these patients carry a high likelihood of these susceptibility genes, we aimed to elucidate the role of angiotensin-converting enzyme (ACE) genetic variants in patients with SZ, BD and their first-degree relatives. 20010451 2010
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.400 Biomarker disease CTD_human Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. 17192785 2007
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker disease CTD_human The risk of prostate cancer development, the PSA level and tumor metastasis may be associated with genetic variation in the ACE I/D genotypes which may be used as an important biomarker for further studies. 17465223 2007
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.400 Biomarker disease CTD_human Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. 17192785 2007
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.400 Biomarker group CTD_human Candidate gene polymorphism in cardiovascular disease: the BIP cohort. 16544732 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 Therapeutic disease CTD_human Amelioration of carcinogenesis and tumor growth in the rat liver by combination of vitamin K2 and angiotensin-converting enzyme inhibitor via anti-angiogenic activities. 16328049 2006
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.400 Biomarker disease CTD_human Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death. 15331425 2004
CUI: C0010200
Disease: Coughing
Coughing 		0.400 Biomarker phenotype CTD_human [A prospective study on the cough mechanism induced by angiotensin-converting enzyme inhibitors in patients with hypertension]. 15498266 2004
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.400 Biomarker disease CTD_human Alzheimer disease risk and genetic variation in ACE: a meta-analysis. 14872014 2004
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.400 Biomarker disease CTD_human Numerous studies have tested for associations between common variants of the angiotensin-converting enzyme gene (ACE) and late-onset Alzheimer disease (AD), but results have been inconclusive. 14872014 2004
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.400 Biomarker group CTD_human Angiotensin-converting enzyme DD genotype is associated with worse perinatal cardiorespiratory adaptation in preterm infants. 14657821 2003
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.400 Biomarker disease CTD_human Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery disease. 14989558 2003
CUI: C0010200
Disease: Coughing
Coughing 		0.400 Biomarker phenotype CTD_human [Study on candidate genes of benazepril related cough in Chinese hypertensives]. 12848919 2003
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.400 Biomarker disease CTD_human Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery disease. 14989558 2003
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.400 Biomarker group CTD_human The ACE gene is a candidate gene for cardiovascular disease. 11498459 2001
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.400 Biomarker disease CTD_human Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population. 10643899 1999
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.400 Biomarker disease CTD_human Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. 9916793 1999
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.400 Biomarker disease CTD_human Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. 9916793 1999
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.400 Biomarker disease CTD_human Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population. 10643899 1999
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis 		0.400 Biomarker disease CTD_human We examined whether the M235T polymorphism of the angiotensinogen (AGT) gene, the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene, and the A1166--> C polymorphism of the angiotensin II type 1 receptor gene may be associated with disease progression in 168 Caucasian patients with IgA nephropathy. 9259580 1997
CUI: C0035078
Disease: Kidney Failure
Kidney Failure 		0.400 Biomarker disease CTD_human Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients. 9259580 1997
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.400 Biomarker disease CTD_human Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients. 9259580 1997
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.400 Biomarker group CTD_human Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. 8642790 1996
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis 		0.400 Biomarker disease CTD_human The results indicate that deletion polymorphism in the ACE gene, particularly the homozygote DD, is a risk factor for progression to chronic renal failure in IgA nephropathy. 7593601 1995
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.400 Biomarker disease CTD_human We have investigated the role of angiotensin-converting enzyme (ACE; EC 3.4.15.1) gene in 316 unrelated NIDDM individuals, 132 who had myocardial infarction or significant coronary stenoses and 184 with no history of coronary heart disease (CHD). 8170965 1994