In the PC, neuroplasticity was assessed by quantifying the same populations of interneurons and a newly identified form of olfactory neuroplasticity mediated by post-mitotic doublecortin (DCX) + immature neurons.We show that T2D dramatically reduced odour detection and olfactory memory.
Moreover, a significant decrease in transcriptional expression of Ki67, DCX, and NeuN was also evident in T2DM brain regions, which indicated possible aberrations in adult hippocampal neurogenesis in T2DM.
Effects of treadmill exercise on cell proliferation and differentiation in the subgranular zone of the dentate gyrus in a rat model of type II diabetes.