Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies have revealed that doublecortin-like kinase 1 (Dclk1) positively regulates tumor growth, invasion, metastasis, factors related to epithelial-mesenchymal transition (EMT), pluripotency, angiogenesis, and anti-apoptosis in pancreatic cancer cells.
|
29048622 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We evaluated the doublecortin-like kinase 1 (DCLK1) expression in human mesothelioma tumors.
|
28560410 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously showed that a tumor/cancer stem cell (CSC) marker, doublecortin-like kinase (DCLK1) positively regulates hepatitis C virus (HCV) replication, and promotes tumor growth in colon and pancreas.
|
25948779 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor stem cell marker Doublecortin-like kinase1 (DCLK1) is upregulated in several solid tumors.
|
26468984 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In order to radiosensitize glioma cells without stimulating invasion, we chose DCX, which is a well-characterized anti-tumor gene, to coexpress with SPARC.
|
23846421 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Doublecortin (DCX) is a microtubule (MT) binding protein that induces growth arrest at the G2-M phase of cell cycle in glioma and suppresses tumor xenograft in immunocompromised hosts.
|
19094064 |
2009 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Double staining of tumour tissue revealed co-expression of doublecortin and neurofilament in cells of gangliocytomas and gangliogliomas and co-expression of doublecortin with S100 protein or GFAP in glial tumours, respectively.
|
16520969 |
2006 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
U87 cells with ectopic expression of DCX exhibit a marked suppression of the transformed phenotype as growth arrested in the G(2) phase of the cell cycle progression, small colony formation in soft agar, and no tumor formation in nude rats.
|
17178868 |
2006 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that DCX would be a more efficient marker of minimal disease in neuroblastoma and perhaps other tumors of neuronal lineage.
|
15714065 |
2005 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
DCX was highly expressed in both high-grade invasive tumors (glioblastoma, n=11; anaplastic astrocytoma/oligoastrocytoma, n=7; and medulloblastoma/PNET, n=6) and low-grade invasive tumors (oligodendroglioma, n=3; and astrocytoma/oligoastrocytoma, n=5).
|
16195916 |
2005 |