DDX5, DEAD-box helicase 5, 1655

N. diseases: 77; N. variants: 3
Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 AlteredExpression disease BEFREE Additionally, p68 positively modulated both mRNA and protein expression levels of Stat3 target genes; promoter activity of Stat3 target gene Mcl-1 in multiple colon cancer cell lines. 27941883 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 AlteredExpression disease BEFREE In addition, p68 increased both AKT messenger RNA (mRNA) and protein, enhanced AKT promoter activity in multiple colon cancer cell lines. 25745998 2015
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 AlteredExpression disease BEFREE Importantly, p68 forms complexes with nuclear β-Catenin and promotes gene transcription in colon cancer indicating a functional interplay between these two proteins in cancer progression. 23349811 2013
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 Biomarker disease BEFREE Therefore, p68 and p72 may be novel targets in the combat against colon cancer. 17699760 2007