|
Cutaneous Fibrous Histiocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Positive smooth muscle actin and factor XIIIa staining in conjunction with negative staining for CD34 and desmin in the current spindled tumor cells are findings consistent with those of cutaneous dermatofibromas.
|
30893190 |
2020 |
|
Exotropia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Desmin, which is downregulated in normal EOMs, had high expression in MR muscles of patients with XT.
|
31630292 |
2020 |
|
Dysferlinopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Western blotting revealed that creatine kinase M-type, carbonic anhydrase III (muscle specific) and desmin were significantly elevated in dysferlinopathy muscle.
|
31439488 |
2020 |
|
Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Baseline characteristics and 3-year clinical outcomes were stratified according to DM status (noninsulin-dependent and insulin-dependent) and DES generation.
|
31288561 |
2019 |
|
Sleep Apnea Syndromes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Desmin and dystrophin abnormalities in upper airway muscles of snorers and patients with sleep apnea.
|
30764835 |
2019 |
|
Desmoplastic fibroma
|
0.010 |
Biomarker
|
disease |
BEFREE |
1/2 of the MS cases were positive for desmin; 6/10 of the DF cases were positive for β-catenin, and 2 of the MF cases were positive for ALK-1.
|
30168888 |
2019 |
|
Smooth Muscle Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Desmin and h-Caldesmon were positive in 90% and 57% of PEComas, and 91% and 82% of SMTs.
|
31851063 |
2019 |
|
Pancreatic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A total of 67.5% and 55.0% of cases positively expressed ACTA2 and DES in pancreatic carcinoma, respectively.
|
30466735 |
2019 |
|
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical staining demonstrated cells labeled with VIM (+), CD68PGM1 (+), CD34 (-), Actin (-), PCK (-), EMA (-), Desmin (-), SMA (-), S-100 (-), P63 (-), ALK-1 (-), beta-catenia (+), and KI67 (+).
|
31169683 |
2019 |
|
Malignant mesothelioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Diagnostic value of BRCA1-associated protein-1, glucose transporter-1 and desmin expression in the discrimination between reactive mesothelial proliferation and malignant mesothelioma in tissues and effusions.
|
31165505 |
2019 |
|
Corneal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
It has remained as yet unproven whether desmin contributes in any significant manner to corneal fibrosis.
|
30590024 |
2019 |
|
3-Methylglutaconic aciduria type 2
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study provides substantial support for translation of an adeno-associated virus serotype 9-mediated TAZ gene replacement strategy using a Des promoter for human BTHS patients in the clinic.
|
30070157 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The coexpression of ACTA2 and DES was related to the expression of MMP2, and positively correlated with lymph node metastasis.
|
30466735 |
2019 |
|
Pelvic Organ Prolapse
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to explore the link between autophagy and collagen metabolism in patients with pelvic organ prolapse (POP) by detecting the expressions of autophagy factors, collagen, desmin, cytokeratin, and vimentin.
|
28786871 |
2019 |
|
Myofibroma (morphologic abnormality)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using a tissue microarray technique (TMA), cases of myofibroma (MF), of nodular fasciitis (NF), of desmoplastic fibroma (DF), and of myofibroblastic sarcoma (MS) from the Universidad Autónoma Metropolitana Xochimilco, and a Private Oral Pathology Service in Mexico City were stained with antibodies against alpha-smooth muscle actin (α-SMA), H-caldesmon, vimentin, desmin, β-catenin, CD34, anaplastic lymphoma protein kinase (ALK-1), and Ki-67.
|
30168888 |
2019 |
|
Cellular neurothekeoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cellular neurothekeoma (CNT) is a dermal lesion with still unknown histogenesis, characterized by immunohistochemical staining for NKI/C3, NSE, MiTF, CD10 and CD68, whereas S100 protein, desmin and cytokeratins are negative.
|
30311258 |
2019 |
|
Solitary Myofibromatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using a tissue microarray technique (TMA), cases of myofibroma (MF), of nodular fasciitis (NF), of desmoplastic fibroma (DF), and of myofibroblastic sarcoma (MS) from the Universidad Autónoma Metropolitana Xochimilco, and a Private Oral Pathology Service in Mexico City were stained with antibodies against alpha-smooth muscle actin (α-SMA), H-caldesmon, vimentin, desmin, β-catenin, CD34, anaplastic lymphoma protein kinase (ALK-1), and Ki-67.
|
30168888 |
2019 |
|
Noncompaction cardiomyopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Noncompaction cardiomyopathy is caused by a novel in-frame desmin (DES) deletion mutation within the 1A coiled-coil rod segment leading to a severe filament assembly defect.
|
30908796 |
2019 |
|
LEUKEMIA, ACUTE LYMPHOBLASTIC, SUSCEPTIBILITY TO, 3
|
0.010 |
Biomarker
|
disease |
BEFREE |
All 3 tumors were immunohistochemically positive for epithelial membrane antigen and desmin.
|
31305268 |
2019 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To study this phenomenon further, human neuronal-glial (HNG) cells in primary culture were incubated with LPS, and DNA arrays, Northern, Western, and ELISA analyses were used to quantify transcription patterns for the three member neuron-specific intermediate filament-gene family NF-H, NF-M, and NF-L. As in sporadic AD limbic-regions, down-regulated transcription products for the NF-L intermediate filament protein was significant.
|
30568571 |
2018 |
|
Cardiovascular Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Our findings suggest that variations in the DES gene may be involved in cardiovascular disease.
|
30096250 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of the intermediate filament protein vimentin has been recently observed in the pancreatic islet β- and α-cells of humans with type 2 diabetes mellitus.
|
29275072 |
2018 |
|
Diabetic Nephropathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The experiments <i>in vivo</i> and <i>in vitro</i> both displayed that the mRNA and protein expression of P2X7R, NLRP3, ASC, caspase1 (procaspase-1 mRNA in the gene level and active caspase-1 subunit P10 in the protein level), IL-1<i>β</i>, and IL-18 was significantly upregulated and the mRNA and protein expression of podocyte-associated molecules was significantly changed (downregulation of nephrin, podocin, and WT-1 expression and upregulation of desmin expression) indicating podocyte injury in the kidney tissue of DN rats and in the HG-stressed mouse podocytes, respectively.
|
30534570 |
2018 |
|
Hypertensive disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Since desmin expression is diminished in vascular smooth muscle cells during reparative processes, we wanted to study whether a common intragenic single nucleotide polymorphism at nucleotide position 828 (rs1058261) of the DES gene associates with hypertension, cerebrovascular complications, and all cardiovascular events in the Tampere adult population cardiovascular risk (TAMRISK) study.
|
30096250 |
2018 |
|
Mediastinal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Thoracoscopic resection of the mediastinal tumor and immunohistological findings, which were positive for smooth muscle actin (SMA), HHF-35, vimentin, and desmin confirmed primary leiomyosarcoma.
|
29607872 |
2018 |