|
Malignant neoplasm of breast
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
This study provides a higher level of evidence that DC-SCRIPT is indeed an independent, pure prognostic, factor for primary breast cancer and shows that DC-SCRIPT mRNA expression is most informative for either ESR1-positive and/or ESR2-low pT1 tumors.
|
21122099 |
2010 |
|
Malignant neoplasm of breast
|
0.550 |
Biomarker
|
disease |
BEFREE |
As loss of DC-SCRIPT expression appears an early event in breast cancer development, we here investigated the role of DC-SCRIPT in mammary gland development using wild-type and DC-SCRIPT knockout mice.
|
31265831 |
2019 |
|
Malignant neoplasm of breast
|
0.550 |
Biomarker
|
disease |
BEFREE |
ZNF366, involved in estrogen metabolism and progression of breast cancer, is a new biologically plausible candidate for endometriosis.
|
25722978 |
2015 |
|
Malignant neoplasm of breast
|
0.550 |
Biomarker
|
disease |
BEFREE |
We recently found that DC-SCRIPT is a prognostic marker in breast cancer and a unique NR coregulator differentially regulating different classes of NRs.
|
22473304 |
2012 |
|
Malignant neoplasm of breast
|
0.550 |
Biomarker
|
disease |
BEFREE |
The effect of DC-SCRIPT on breast cancer cell growth and cell cycle arrest was investigated using novel DC-SCRIPT-inducible MCF7 breast cancer cell lines.
|
25663546 |
2015 |
|
Breast Carcinoma
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
This study provides a higher level of evidence that DC-SCRIPT is indeed an independent, pure prognostic, factor for primary breast cancer and shows that DC-SCRIPT mRNA expression is most informative for either ESR1-positive and/or ESR2-low pT1 tumors.
|
21122099 |
2010 |
|
Breast Carcinoma
|
0.550 |
Biomarker
|
disease |
BEFREE |
We recently found that DC-SCRIPT is a prognostic marker in breast cancer and a unique NR coregulator differentially regulating different classes of NRs.
|
22473304 |
2012 |
|
Breast Carcinoma
|
0.550 |
Biomarker
|
disease |
BEFREE |
As loss of DC-SCRIPT expression appears an early event in breast cancer development, we here investigated the role of DC-SCRIPT in mammary gland development using wild-type and DC-SCRIPT knockout mice.
|
31265831 |
2019 |
|
Breast Carcinoma
|
0.550 |
Biomarker
|
disease |
BEFREE |
The effect of DC-SCRIPT on breast cancer cell growth and cell cycle arrest was investigated using novel DC-SCRIPT-inducible MCF7 breast cancer cell lines.
|
25663546 |
2015 |
|
Breast Carcinoma
|
0.550 |
Biomarker
|
disease |
BEFREE |
ZNF366, involved in estrogen metabolism and progression of breast cancer, is a new biologically plausible candidate for endometriosis.
|
25722978 |
2015 |
|
Mammary Neoplasms
|
0.510 |
AlteredExpression
|
group |
BEFREE |
DC-SCRIPT mRNA levels from 190 primary ESR1-positive breast tumors were related to global gene expression, followed by gene ontology and pathway analysis.
|
25663546 |
2015 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
This study provides a higher level of evidence that DC-SCRIPT is indeed an independent, pure prognostic, factor for primary breast cancer and shows that DC-SCRIPT mRNA expression is most informative for either ESR1-positive and/or ESR2-low pT1 tumors.
|
21122099 |
2010 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In addition, in the presence of DC-SCRIPT, multiple cell cycles related genes were differentially expressed including the tumor suppressor gene CDKN2B.
|
25663546 |
2015 |
|
Alcoholic Intoxication, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, gene-based tests identified a genome-wide significant gene, ZNF366, a negative regulator of glucocorticoid receptor function implicated in alcohol dependence (p = 1.48x10-7; Bonferroni-corrected significance threshold p < 2.79x10-6).
|
30571770 |
2018 |
|
Endometriosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
ZNF366, involved in estrogen metabolism and progression of breast cancer, is a new biologically plausible candidate for endometriosis.
|
25722978 |
2015 |
|
Endometrioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Rs4703908, located close to ZNF366, provided a higher risk of OMA (OR = 2.22; 95% CI: 1.26-3.92) and DIE, especially with bowel involvement (OR = 2.09; 95% CI: 1.12-3.91).
|
25722978 |
2015 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we investigated the importance of DC-SCRIPT in prostate cancer.
|
22473304 |
2012 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Strikingly, DC-SCRIPT protein expression was absent in malignant prostate epithelial tissue and prostate carcinoma cell lines.
|
22473304 |
2012 |
|
Chocolate cyst of ovary
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Rs4703908, located close to ZNF366, provided a higher risk of OMA (OR = 2.22; 95% CI: 1.26-3.92) and DIE, especially with bowel involvement (OR = 2.09; 95% CI: 1.12-3.91).
|
25722978 |
2015 |
|
Oestrogen receptor positive breast cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have previously identified the loss of expression of the transcription regulator DC-SCRIPT (Zfp366) as a prominent prognostic event in estrogen receptor positive breast cancer patients.
|
31265831 |
2019 |
|
Malignant neoplasm of breast
|
0.550 |
Biomarker
|
disease |
CTD_human |
DC-SCRIPT: nuclear receptor modulation and prognostic significance in primary breast cancer.
|
20008677 |
2010 |
|
Breast Carcinoma
|
0.550 |
Biomarker
|
disease |
CTD_human |
DC-SCRIPT: nuclear receptor modulation and prognostic significance in primary breast cancer.
|
20008677 |
2010 |
|
Mammary Neoplasms
|
0.510 |
Biomarker
|
group |
CTD_human |
DC-SCRIPT: nuclear receptor modulation and prognostic significance in primary breast cancer.
|
20008677 |
2010 |
|
Mammary Neoplasms, Human
|
0.500 |
Biomarker
|
disease |
CTD_human |
DC-SCRIPT: nuclear receptor modulation and prognostic significance in primary breast cancer.
|
20008677 |
2010 |
|
Mammary Carcinoma, Human
|
0.500 |
Biomarker
|
disease |
CTD_human |
DC-SCRIPT: nuclear receptor modulation and prognostic significance in primary breast cancer.
|
20008677 |
2010 |