CFD, complement factor D, 1675

N. diseases: 83; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1536085
Disease: Geographic Atrophy
Geographic Atrophy
0.020 Biomarker disease BEFREE The complement factor D inhibitor, lampalizumab, failed to halt geographic atrophy (GA) progression in phase 3 studies. 30686077 2019
CUI: C1536085
Disease: Geographic Atrophy
Geographic Atrophy
0.020 Biomarker disease BEFREE Several clinical trials designed to interfere specifically with these pathomechanisms have yielded rather disappointing results, although a phase II study of the monoclonal antibody lampalizumab showed that blocking complement factor D lessened the progression of geographic atrophy. 24622760 2014