|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3.
|
22158537 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We also provide evidence for the first time in South Asians that alleles of SNPs in GLIS3 and ADCY5 may confer risk of type 2 diabetes.
|
21949744 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
SNPs from GIPR, TCF7L2, CRY2, GLIS3 and SLC30A8 were also associated with type 2 diabetes (p = 0.0487∼2.0×10(-8)).
|
21103350 |
2010 |
|
Congenital Hypothyroidism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.
|
16715098 |
2006 |
|
Congenital Hypothyroidism
|
0.500 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.
|
16715098 |
2006 |
|
Congenital Hypothyroidism
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Diabetes Mellitus, Insulin-Dependent
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
Importantly, genome-wide association studies showed that variations of GLIS3 are strongly associated with both type 1 diabetes (T1D) and type 2 diabetes (T2D) in multiple populations.
|
27899417 |
2017 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the aim of this study was to replicate the association of the rs10758593 and rs7020673 single nucleotide polymorphisms (SNPs) in the GLIS3 gene with T1DM in a Brazilian population.
|
28597135 |
2017 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.440 |
Biomarker
|
disease |
BEFREE |
GLIS3 is a key transcription factor in insulin production and β-cell differentiation during embryonic development, which perturbation forms the basis of monogenic diabetes as well as its association with T1D.
|
27035557 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
|
25751624 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
The association analysis of the low-frequency variants revealed that only the A908V variant of GLIS3 was strongly associated with resistance to T1D (Haldane's odds ratio = 0.046, p = 8.21 × 10(-4), and pc=2.22 × 10(-2)).
|
23856252 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
|
21980299 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.440 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
Fibrosis, Liver
|
0.420 |
AlteredExpression
|
disease |
BEFREE |
Given the role of GLIS3 in transcriptional activation and repression during embryogenesis, in humans, GLIS3 mutations present with multisystem involvement that also includes renal cystic dysplasia, progressive liver fibrosis and osteopenia.
|
28648506 |
2017 |
|
Fibrosis, Liver
|
0.420 |
GeneticVariation
|
disease |
BEFREE |
Mutations in human GLIS3 have been implicated in a syndrome characterized by neonatal diabetes and congenital hypothyroidism (NDH) and in some patients accompanied by polycystic kidney disease, glaucoma, and liver fibrosis.
|
20865670 |
2010 |
|
Fibrosis, Liver
|
0.420 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.
|
16715098 |
2006 |
|
Fibrosis, Liver
|
0.420 |
Biomarker
|
disease |
HPO |
|
|
|
|
Neonatal diabetes mellitus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Loss of GLIS3 function in humans and mice leads to the development of several pathologies, including neonatal diabetes and congenital hypothyroidism, polycystic kidney disease, and infertility.
|
29779043 |
2018 |
|
Neonatal diabetes mellitus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes, reflecting a key function for this gene in pancreatic β-cell biology.
|
29992946 |
2018 |
|
Neonatal diabetes mellitus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Defects in the human GLI-similar 3 (GLIS3) gene are reported to be a rare cause of congenital hypothyroidism (CH) and neonatal diabetes.
|
29146476 |
2018 |
|
Neonatal diabetes mellitus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We suggest that infants with neonatal diabetes associated with dysmorphism should be screened for GLIS3 gene mutations.
|
28253873 |
2017 |
|
Neonatal diabetes mellitus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations in GLIS3 cause a neonatal diabetes syndrome, characterized by neonatal diabetes, congenital hypothyroidism and polycystic kidney.
|
27899417 |
2017 |
|
Neonatal diabetes mellitus
|
0.400 |
Biomarker
|
disease |
BEFREE |
The association of permanent neonatal diabetes and congenital hypothyroidism was first reported in 2003 and subsequently led to the identification GLIS3 as the mutation responsible for this presentation.
|
28648506 |
2017 |