GLIS3, GLIS family zinc finger 3, 169792

N. diseases: 105; N. variants: 48
Disease: Alzheimer's Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.120 Biomarker disease BEFREE The GLIS family zinc finger 3 isoform (GLIS3) is a risk gene for Type 1 and Type 2 diabetes, glaucoma and Alzheimer's disease endophenotype. 28911974 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.120 GeneticVariation disease GWASCAT GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. 23562540 2013
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.120 GeneticVariation disease BEFREE We performed the largest genome-wide association study for cerebrospinal fluid (CSF) tau/ptau levels published to date (n = 1,269), identifying three genome-wide significant loci for CSF tau and ptau: rs9877502 (p = 4.89 × 10⁻⁹ for tau) located at 3q28 between GEMC1 and OSTN, rs514716 (p = 1.07 × 10⁻⁸ and p = 3.22 × 10⁻⁹ for tau and ptau, respectively), located at 9p24.2 within GLIS3 and rs6922617 (p = 3.58 × 10⁻⁸ for CSF ptau) at 6p21.1 within the TREM gene cluster, a region recently reported to harbor rare variants that increase AD risk. 23562540 2013