Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Here, we present a treatment strategy that makes BER inhibition tumor-selective and NQO1-dependent for therapy of most solid neoplasms, particularly for pancreatic cancer.
|
26602448 |
2015 |
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
A novel anticancer agent RH1 is designed as pro-drug to be activated by NQO1, an enzyme overexpressed in many types of tumors.
|
28879492 |
2017 |
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This genomic gain was associated with amplification of the NQO1 gene in one tumor biopsy as well as in breast cancer cell lines.
|
26687450 |
2016 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Agents, such as β-lapachone, that target the redox enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1), to induce programmed necrosis in solid tumors have shown great promise, but more potent tumor-selective compounds are needed.
|
22532167 |
2012 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Protection from tumor formation is associated with elevation of Phase II enzymes, including glutathione (GSH) transferase and NAD(P)H:quinone oxidoreductase (DT-diaphorase) in experimental carcinogenesis models in vivo.
|
9815750 |
1997 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The positive rate of NQO1 was related with clinical stage and lymph node metastasis, and the strongly positive rate of NQO1 protein was significantly correlated with tumor size, poor differentiation, advanced clinical stage and lymph node metastasis in NSCLC.
|
25880877 |
2015 |
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
NQO1 protein expression was associated with estrogen receptor (ER) expression (P = 0.011), whereas 34.5% of NFκB-nuclear/activated tumors were ER negative (P = 0.001).
|
21706157 |
2012 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Previous studies have shown that depleting tumor-NQO1 potentiates anoikis and inhibits growth of NSCLC.
|
29291405 |
2018 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, the intracellular delivery of RNase A-QPN using a novel type of lipid-based nanoparticles, and subsequent protein activation by cellular NQO1, selectively inhibit cancer cell growth in vitro and effectively suppress tumor growth in vivo.
|
31589435 |
2019 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
NQO1 deficiency promotes estrogen-dependent tumor formation, and shikonin inhibits estrogen-dependent tumor growth in an NQO1-dependent manner in MCF-7 xenografts.
|
20623181 |
2010 |
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Tumor sensitivity to MMC, as indicated by the inverse of IC(50) values, was positively correlated with the expression of DTD (r(2), 0.28; P < 0.05) and P450R (r(2), 0.26; P < 0.05).
|
11350900 |
2001 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
NQO1 is known to catalyse metabolic detoxification of quinones and protect cells from redox cycling, oxidative stress and neoplasia.
|
11154737 |
2000 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Therefore, our findings support that NQO1 displays a paradoxical role in mediating GBM growth in response to tumor suppressor PTEN.
|
30595797 |
2018 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In the case of MMC, however, the work presented here demonstrates that genotyping of individuals with respect to NQO1 is unlikely to be beneficial in terms of predicting tumor responses to MMC.
|
11709197 |
2001 |
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genetically determined variations in NQO1 may modify the risk for CRC and these risks may be greatest for tumors containing K-ras codon 12 mutations.
|
11023538 |
2000 |
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Secondary objectives were assessment of toxicity, pharmacokinetic determination of RH1 and pharmacodynamic assessment of drug effect through measurement of DNA cross linking in peripheral blood mononuclear cells (PBMCs) and tumour, DTD activity in tumour and NAD(P)H:quinone oxidoreductase 1 (NQO1) polymorphism status.
|
21378203 |
2011 |
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We found that NQO1 was frequently up-regulated in human liver cancer, and its high expression level was correlated with the tumor stage and low survival rate of HCC patients.
|
30867140 |
2019 |
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Developing an effective method for detecting NQO1 activity with high sensitivity and selectivity in tumors holds a great potential for cancer diagnosis, treatment, and management.
|
30487423 |
2018 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Here, we demonstrate that NQO1-targeting prodrug β-lapachone triggers tumor-selective innate sensing leading to T cell-dependent tumor control.
|
31324798 |
2019 |
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Tumour tissue was analysed for NQO1 expression.
|
30318513 |
2018 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
NAD(P)H quinone oxidoreductase 1 (NQO1)-dependent antitumor drugs such as β-lapachone (β-lap) are attractive candidates for cancer chemotherapy because several tumors exhibit higher expression of NQO1 than adjacent tissues.
|
29434949 |
2018 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
This translational study offers a potential biomarker-driven strategy using NQO1 expression to select tumors susceptible to β-lap-induced radiosensitization.
|
27196777 |
2016 |
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
NQO1 overexpression correlated to tumor size, venous infiltration and late pTNM stage of HCC.
|
28964792 |
2017 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a key enzyme involved in defence against reactive forms of oxygen and inhibition of neoplasia.
|
15476858 |
2004 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
These data suggest that RH1 may be an effective NQO1-directed antitumor agent for the therapy of tumors with elevated NQO1 activity, such as NSCLC.
|
9865924 |
1998 |