DLG2, discs large MAGUK scaffold protein 2, 1740

N. diseases: 44; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 GeneticVariation group BEFREE A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A. 7590743 1995
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.020 GeneticVariation disease BEFREE Since allelic loss has been reported in the 17q12-q21 region in breast and ovarian cancer and it appears that BRCA1 is not the target of the losses, we looked for somatic alterations in DLG2 in sporadic breast tumors. 7590743 1995
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.020 GeneticVariation disease BEFREE Since allelic loss has been reported in the 17q12-q21 region in breast and ovarian cancer and it appears that BRCA1 is not the target of the losses, we looked for somatic alterations in DLG2 in sporadic breast tumors. 7590743 1995
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial 		0.020 GeneticVariation disease BEFREE Since allelic loss has been reported in the 17q12-q21 region in breast and ovarian cancer and it appears that BRCA1 is not the target of the losses, we looked for somatic alterations in DLG2 in sporadic breast tumors. 7590743 1995
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.010 GeneticVariation group BEFREE Since allelic loss has been reported in the 17q12-q21 region in breast and ovarian cancer and it appears that BRCA1 is not the target of the losses, we looked for somatic alterations in DLG2 in sporadic breast tumors. 7590743 1995
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.460 Biomarker disease BEFREE These results suggest that PSZA11q14 may be considered a candidate gene for schizophrenia acting as an antisense regulator of DLG-2, which controls assembling functional N-methyl-D-aspartate (NMDA) receptors. 13130513 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.460 Biomarker disease PSYGENET These results suggest that PSZA11q14 may be considered a candidate gene for schizophrenia acting as an antisense regulator of DLG-2, which controls assembling functional N-methyl-D-aspartate (NMDA) receptors. 13130513 2003
CUI: C0809983
Disease: Schizophrenia and related disorders
Schizophrenia and related disorders 		0.300 Biomarker group PSYGENET Novel putative nonprotein-coding RNA gene from 11q14 displays decreased expression in brains of patients with schizophrenia. 13130513 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.460 Biomarker disease PSYGENET We found decreased striatal expression of transcripts encoding PSD-95 and SAP-102 in bipolar disorder and of SAP-102 in major depression and schizophrenia, while no significant changes in NF--L and PSD-93 mRNAs were observed. 16023328 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.300 Biomarker disease PSYGENET We found decreased striatal expression of transcripts encoding PSD-95 and SAP-102 in bipolar disorder and of SAP-102 in major depression and schizophrenia, while no significant changes in NF--L and PSD-93 mRNAs were observed. 16023328 2005
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.300 Biomarker disease PSYGENET We found decreased striatal expression of transcripts encoding PSD-95 and SAP-102 in bipolar disorder and of SAP-102 in major depression and schizophrenia, while no significant changes in NF--L and PSD-93 mRNAs were observed. 16023328 2005
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.300 Biomarker disease PSYGENET We found decreased striatal expression of transcripts encoding PSD-95 and SAP-102 in bipolar disorder and of SAP-102 in major depression and schizophrenia, while no significant changes in NF--L and PSD-93 mRNAs were observed. 16023328 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.460 Biomarker disease PSYGENET We found significant changes in the expression of NF-L in DLPFC, and PSD-95 and PSD-93 in ACC; increased transcript expression was associated with decreased protein expression, suggesting abnormal translation and/or accelerated protein degradation of these molecules in schizophrenia. 16702973 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.460 AlteredExpression disease BEFREE We found significant changes in the expression of NF-L in DLPFC, and PSD-95 and PSD-93 in ACC; increased transcript expression was associated with decreased protein expression, suggesting abnormal translation and/or accelerated protein degradation of these molecules in schizophrenia. 16702973 2006
CUI: C0022665
Disease: Kidney Neoplasm
Kidney Neoplasm 		0.010 AlteredExpression disease BEFREE The new isoform is specifically upregulated in renal oncocytoma, whereas the known DLG2 gene is downregulated in this type of kidney tumour. 16640776 2006
CUI: C0346255
Disease: Oncocytoma, renal
Oncocytoma, renal 		0.010 Biomarker disease BEFREE The new isoform of DLG2 is the promising candidate gene for molecular differential diagnostics of renal oncocytoma. 16640776 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.300 Biomarker disease PSYGENET We performed in situ hybridization to assess hippocampal expression of the transcripts encoding NMDA receptor subunits NR1, 2A, 2B, 2C and 2D, and the transcripts for the NMDA receptor associated PSD proteins PSD95, PSD93, NF-L, and SAP102 in subjects with schizophrenia, bipolar affective disorder I, and a comparison group. 17113057 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.460 Biomarker disease PSYGENET Using this system we focused on three postsynaptic proteins DISC1, TNIK and PSD-93/DLG2 each of which is encoded by a schizophrenia susceptibility gene. 21440632 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.460 Biomarker disease BEFREE Using this system we focused on three postsynaptic proteins DISC1, TNIK and PSD-93/DLG2 each of which is encoded by a schizophrenia susceptibility gene. 21440632 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.300 Biomarker disease CTD_human Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation. 22535842 2012
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.100 GeneticVariation disease GWASCAT A genome-wide association study identifies susceptibility loci for Wilms tumor. 22544364 2012
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.100 GeneticVariation disease GWASDB A genome-wide association study identifies susceptibility loci for Wilms tumor. 22544364 2012
CUI: C0202177
Disease: Phospholipid measurement
Phospholipid measurement 		0.100 GeneticVariation phenotype GWASDB Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. 22359512 2012
CUI: C0202177
Disease: Phospholipid measurement
Phospholipid measurement 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. 22359512 2012
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.110 GeneticVariation disease GWASCAT Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. 25064009 2014