DLX3, distal-less homeobox 3, 1747

N. diseases: 67; N. variants: 5
Disease: Fetal Growth Retardation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.030 AlteredExpression phenotype BEFREE IDO and TDO mRNA and protein expression, responsible for kynurenine production from tryptophan, were significantly lower in placentas from FGR pregnancies compared with control. 28454699 2017
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.030 AlteredExpression phenotype BEFREE We conclude that DLX3 orchestrates the expression of multiple regulators of trophoblast differentiation and that expression of these regulatory genes is abnormal in FGR. 23831639 2013
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.030 AlteredExpression phenotype BEFREE Therefore, we conclude that increased DLX3 expression in FGR may contribute to trophoblast dysfunction observed in FGR. 22113468 2012