|
Back Pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The approach using low BMD or back pain had the highest sensitivity (75%), lowest specificity (64%), lowest PPV (20%), and highest NPV (95%).
|
31742768 |
2020 |
|
Subclinical hypothyroidism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, BMD at the lower distal and ultradistal forearms might be affected by subclinical hyperthyroidism, and higher femur neck BMD could be affected by subclinical hypothyroidism.
|
31721088 |
2020 |
|
Neuropsychiatric syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Dystrophin protein 71 (Dp71) is the major DMD gene product expressed in the brain and mutations affecting its expression are associated with the DMD neuropsychiatric syndrome.
|
31836945 |
2020 |
|
Metabolic Bone Disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
If our results are confirmed in prospective studies, SIB could be used-together with BMD and TBS-to improve the fracture risk assessment and support the clinical decision to assume specific drugs for metabolic bone diseases.
|
31805121 |
2019 |
|
Coxsackievirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
The mechanism of myocyte injury by coxsackie virus was identified in protease 2A coded by the virus and disrupting the dystrophin in the cytoskeleton.
|
31378380 |
2019 |
|
Cushing Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subtle cortisol excess in premenopausal women and reduced DHEA-S in postmenopausal women and men may contribute to BMD reduction in Asians with SH.
|
30719548 |
2019 |
|
Dermatitis Herpetiformis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Abbreviations: AGA: anti-gliadin antibodies; Anti-DGP-ab: anti-deamidated gliadin peptide antibodies; Anti-tTG-ab: anti-tissue transglutaminase antibodies; ATD: auto-immune thyroid disorders; BMD: bone mineral density; CD: coeliac disease; DH: dermatitis herpetiformis; EMA: anti-endomysial antibodies; FDR: first-degree relatives; GFD: gluten-free diet; HbA1c: haemoglobin A1c; HLA: human leucocyte antigen; IBS: irritable bowel syndrome; LMIC: low- and middle-income countries; NPV: negative predictive value; NRCD: non-responsive coeliac disease; POCT: point-of-care tests; SDR: second-degree relatives; SIBO: small intestinal bacterial overgrowth; T1DM: type 1 diabetes mellitus; ULN: upper limit of normal.
|
30099930 |
2019 |
|
Down Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis of volumetric BMD in people with Down syndrome using DXA-based 3D modeling.
|
31494745 |
2019 |
|
Gastrointestinal Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Analysis of 318 STS by CGH array evidenced a frequent deletion affecting the <i>DMD</i> gene (encoding dystrophin isoforms) in 16.5% of STS, including sarcomas with complex genomics, gastrointestinal tumors (GIST), and synovial sarcomas (SS).
|
31266185 |
2019 |
|
Hypercalcemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In, women with osteoporosis, abaloparatide increased BMD faster than TPTD and decreased fracture risk at both vertebral and non-vertebral sites but unlike TPTD/PTH did not increase resorption or hypercalcemia.
|
31136739 |
2019 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Extra attention towards frequent hyperglycemia in CF patients should be taken when evaluating decreased BMD.
|
30928333 |
2019 |
|
Irritable Bowel Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Abbreviations: AGA: anti-gliadin antibodies; Anti-DGP-ab: anti-deamidated gliadin peptide antibodies; Anti-tTG-ab: anti-tissue transglutaminase antibodies; ATD: auto-immune thyroid disorders; BMD: bone mineral density; CD: coeliac disease; DH: dermatitis herpetiformis; EMA: anti-endomysial antibodies; FDR: first-degree relatives; GFD: gluten-free diet; HbA1c: haemoglobin A1c; HLA: human leucocyte antigen; IBS: irritable bowel syndrome; LMIC: low- and middle-income countries; NPV: negative predictive value; NRCD: non-responsive coeliac disease; POCT: point-of-care tests; SDR: second-degree relatives; SIBO: small intestinal bacterial overgrowth; T1DM: type 1 diabetes mellitus; ULN: upper limit of normal.
|
30099930 |
2019 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using dystrophin immunohistochemistry for membrane staining, human post-infarction myocardial tissue was assessed.
|
31417141 |
2019 |
|
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Data from human diseases or dysfunctions identified 19 genes whose mutation was associated with human BMD: 9 genes each for human height and osteoporosis; 4 genes each for human osteoarthritis (OA) and fracture risk; and 2 genes each for adolescent idiopathic scoliosis (AIS), periodontitis, osteosarcoma growth, and tooth development.
|
31646011 |
2019 |
|
Periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Data from human diseases or dysfunctions identified 19 genes whose mutation was associated with human BMD: 9 genes each for human height and osteoporosis; 4 genes each for human osteoarthritis (OA) and fracture risk; and 2 genes each for adolescent idiopathic scoliosis (AIS), periodontitis, osteosarcoma growth, and tooth development.
|
31646011 |
2019 |
|
Seizures
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Status epilepticus (a prolonged seizure activity, SE) differently affects vasogenic edema formation and dystrophin-aquaporin 4 (AQP4) expressions between the rat hippocampus and the piriform cortex (PC).
|
31795399 |
2019 |
|
Sleep Apnea Syndromes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cytoskeletal proteins desmin and dystrophin were morphologically evaluated in the uvula muscle of 22 patients undergoing soft palate surgery due to snoring and sleep apnea and in 10 healthy controls.
|
30764835 |
2019 |
|
Snoring
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Cytoskeletal proteins desmin and dystrophin were morphologically evaluated in the uvula muscle of 22 patients undergoing soft palate surgery due to snoring and sleep apnea and in 10 healthy controls.
|
30764835 |
2019 |
|
Androgen-Insensitivity Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Data from human diseases or dysfunctions identified 19 genes whose mutation was associated with human BMD: 9 genes each for human height and osteoporosis; 4 genes each for human osteoarthritis (OA) and fracture risk; and 2 genes each for adolescent idiopathic scoliosis (AIS), periodontitis, osteosarcoma growth, and tooth development.
|
31646011 |
2019 |
|
Thyroid Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Abbreviations: AGA: anti-gliadin antibodies; Anti-DGP-ab: anti-deamidated gliadin peptide antibodies; Anti-tTG-ab: anti-tissue transglutaminase antibodies; ATD: auto-immune thyroid disorders; BMD: bone mineral density; CD: coeliac disease; DH: dermatitis herpetiformis; EMA: anti-endomysial antibodies; FDR: first-degree relatives; GFD: gluten-free diet; HbA1c: haemoglobin A1c; HLA: human leucocyte antigen; IBS: irritable bowel syndrome; LMIC: low- and middle-income countries; NPV: negative predictive value; NRCD: non-responsive coeliac disease; POCT: point-of-care tests; SDR: second-degree relatives; SIBO: small intestinal bacterial overgrowth; T1DM: type 1 diabetes mellitus; ULN: upper limit of normal.
|
30099930 |
2019 |
|
Corneal Neovascularization
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that dystrophin Dp71 could play an important role as a negative regulator of corneal angiogenesis.
|
31814696 |
2019 |
|
Disuse osteoporosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Retrospective chart review of IV BP for treatment of disuse osteoporosis and low BMD in children with SMA at a tertiary pediatric center from 2010 to 2018 RESULTS: Eight patients (50% female; 75% SMA type 1; median age at first infusion 6.7 years) receiving a total of 39 infusions (54% pamidronate, 46% zoledronic acid) were included in this report.
|
31788718 |
2019 |
|
Cerebral atrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
In Duchenne and Becker muscular dystrophies (DMD, BMD) cortical atrophy is associated with minimal ventricular dilatation and WM abnormalities.
|
31105770 |
2019 |
|
Difficulty passing urine
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Dystrophin is expressed in smooth muscle cells and afferent nerve fibers in the urinary bladder, which underscores that micturition problems in DMD may have not solely a myogenic but also a neurogenic origin.Muscle Nerve 60: 202-210, 2019.
|
31095755 |
2019 |
|
Ventricular dilatation (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
In Duchenne and Becker muscular dystrophies (DMD, BMD) cortical atrophy is associated with minimal ventricular dilatation and WM abnormalities.
|
31105770 |
2019 |