DMD, dystrophin, 1756

N. diseases: 484; N. variants: 345
Disease: Cardiomyopathies ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.700 Biomarker group BEFREE We recently identified cleavage and functional impairment of dystrophin by the viral protease 2A during CVB3-infection as a molecular mechanism that may contribute to the pathogenesis of enterovirus-induced cardiomyopathy. 11056105 2000
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.700 Therapeutic group CTD_human Systemic administration of micro-dystrophin restores cardiac geometry and prevents dobutamine-induced cardiac pump failure. 17440445 2007
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.700 Biomarker group BEFREE Lack of dystrophin also results to cardiomyopathy, which raises significantly the stroke risk in DMD-patients. 29552091 2018
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.700 Biomarker group BEFREE Previously, treatment with β-blockers showed beneficial effects on the development of cardiomyopathy in dystrophin-deficient (mdx) mice, but not in δ-sarcoglycan-deficient (Sgcd-/-) mice. 30782477 2019
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.700 Biomarker group HPO
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.700 Biomarker group BEFREE Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex. 21665956 2011
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.700 Biomarker group BEFREE Dystrophin Cardiomyopathies: Clinical Management, Molecular Pathogenesis and Evolution towards Precision Medicine. 30235804 2018
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.700 Biomarker group CTD_human Intolerance to ß-blockade in a mouse model of δ-sarcoglycan-deficient muscular dystrophy cardiomyopathy. 20675662 2010
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.700 AlteredExpression group BEFREE The absence of dystrophin and the down-regulation of the dystrophin-associated proteins in the heart accounted for the severe cardiomyopathy in this family. 7635962 1995