|
Osteoporotic Fractures
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Evaluation was completed for patients, aged 50-80 years with a BMD T-score ≤ -3.5 or with a T-score between -2.5 and -3.5 and a history of ≥ one osteoporotic fracture.
|
30737062 |
2019 |
|
Osteoporotic Fractures
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Risk of osteoporotic fractures in SCI is predicted by a combination of DXA-defined low BMD plus clinical and demographic characteristics.
|
29745791 |
2019 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
The stiffness index (SI) from quantitative ultrasound measurements is a good indicator of BMD and may be used to predict the risk of osteoporotic fracture.
|
30779856 |
2019 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
After multivariable adjustment, including for total hip areal BMD, decreased HR-pQCT finite element analysis EFL for each site was associated with significantly greater odds of prior confirmed clinical fracture and major osteoporotic fracture.
|
29751130 |
2018 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
Meta-analytic data confirm the effectiveness of an FLS following an osteoporotic fracture: approximate 27% increase in the likelihood of BMD testing and up to 21% increase in the likelihood of treatment initiation compared with usual care.
|
29525971 |
2018 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
Participants (n = 4379; mean age 72.9 ± 5.5 years) were from the Osteoporotic Fractures in Men (MrOS) prospective cohort study and had dietary data collected at baseline (March 2000-April 2002) and BMD measured at baseline and Visit 2 (March 2005-May 2006).
|
29450584 |
2018 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
In two sub-groups, BMD- and age-matched, respectively, Ct.FD remained significantly lower in HF than HOA (p < 0.001).
|
29249023 |
2018 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
The best discrimination between women with and without fracture was obtained at the radius with total vBMD, the combination of a Tb with a Ct parameter, or with failure load, which improved the area under the curve (AUC) for major osteoporotic fracture when added to FN aBMD (0.760 versus 0.695, p = 0.022) or to FRAX-BMD (0.759 versus 0.714, p = 0.015).
|
28960489 |
2018 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study population was 3969 Osteoporotic Fractures in Men (MrOS) cohort participants (mean age 72.8 years) with repeat measures of TBS, lumbar spine and total hip BMD, body mass index (BMI) less than 37 kg/m<sup>2</sup>, and no use of bisphosphonate or glucocorticoid medications.
|
29090329 |
2018 |
|
Osteoporotic Fractures
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The FRAX algorithm estimates the patient's 10-year probability of sustaining an osteoporotic fracture and can be calculated with or without BMD data.
|
29397409 |
2018 |
|
Osteoporotic Fractures
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this study we use a recently developed novel pleiotropic conditional false discovery rate (cFDR) method to identify novel genetic loci associated with two risk traits for osteoporotic fracture (the clinical outcome and end result of osteoporosis), Height (HT) and Femoral Neck (FNK) BMD.
|
28373146 |
2017 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
BMD and T-scores at the lumbar spine were not significantly associated with osteoporotic fractures (p > 0.48) for both.
|
27924381 |
2017 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
When a BMD T-score of -2.5 SD was used as an intervention threshold, FRAX probabilities of a major osteoporotic fracture in women aged 50 years were approximately twofold higher than those in women of the same age but with an average BMD.
|
28782072 |
2017 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
The FRAX® tool was used in conjunction with BMD and trabecular bone score (TBS) adjustment to estimate major osteoporotic fracture probability later in life resulting from varying degrees of hypothetical premenopausal drug-induced BMD and TBS loss.
|
29018923 |
2017 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
The objective of this study was to examine the rates of low-trauma fracture and BMD testing among a population-based cohort of people with IDD and compare them to those without IDD.
|
27613720 |
2017 |
|
Osteoporotic Fractures
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Utilizing 2005-2008 data of the National Health and Nutrition Examination Survey (NHANES), we identified participants with osteoporosis with any one of the following: (1) femoral neck or lumbar spine T-score ≤ -2.5; (2) low trauma hip fracture irrespective of BMD or clinical vertebral, proximal humerus, pelvis, or distal forearm fracture with a T-score >-2.5 <-1.0; or (3) FRAX score at the National Osteoporosis Foundation intervention thresholds (≥3% for hip fracture or ≥20% for major osteoporotic fracture).
|
27966104 |
2017 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
A haplotype comprising all the common alleles (frequency 9%) was associated with decreased bone loss at the hip (p < 0.05) and decreased incidence of osteoporotic fractures (p < 0.05) in DOPS and increased femoral neck BMD in AROS (p < 0.05).
|
21104233 |
2011 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
The SNPs were genotyped and evaluated for association with BMD at the lumbar spine (LS) or femoral neck (FN) and with osteoporotic fracture, at single SNP and haplotype levels, by regression methods.
|
18684085 |
2008 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
Nonsynonymous single nucleotide polymorphisms (SNPs) in the human LEPR gene have been associated with adiposity in a number of studies, but there have been no large-scale studies of their implications for BMD and osteoporotic fracture risk in postmenopausal women.
|
17243864 |
2007 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
Populations of African ancestry have lower osteoporotic fracture risk and higher BMD than other ethnic groups.
|
17227221 |
2007 |
|
Osteoporotic Fractures
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Association of FLT3 polymorphisms with low BMD and risk of osteoporotic fracture in postmenopausal women.
|
17620055 |
2007 |
|
Osteoporotic Fractures
|
0.100 |
Biomarker
|
group |
BEFREE |
BMD is the major factor for determining bone strength and osteoporotic fracture risk and is determined by both environmental and multiple genetic factors.
|
16007331 |
2005 |
|
Osteoporotic Fractures
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, we have demonstrated that the rare TT genotype of the C677T polymorphism in the MTHFR gene is associated with increased risk of osteoporotic fractures in women and a weak predictor of lumbar spine BMD.
|
15300362 |
2005 |
|
Osteoporotic Fractures
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our data do not support the hypothesis that the ApoE*4 risk allele is associated with BMD, increased bone loss, or an increased risk of osteoporotic fractures.
|
15312249 |
2004 |
|
Osteoporotic Fractures
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this study, we evaluated the relationship between the IL-6 G-174C polymorphism and BMD, the rate of decline in BMD, and the risk of fracture in 3376 women 65 years of age and older participating in the Study of Osteoporotic Fractures.
|
15355555 |
2004 |