|
Diabetic Retinopathy
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
MSP results showed that there were 26 cases (32.50%) of RAGE gene promoter methylation in PBMCs in DR patients.
|
29375686 |
2018 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Studies were on human subjects; the studies were case-control ones and included subjects who had DR and those who did not have DR; and the studies provided genotype data for genetic variants in RAGE, separately for subjects who had and did not have DR, or provided odds ratios (ORs) and the 95% confidence intervals (CIs), or provided sufficient data for the calculation of OR and the 95% CI.
|
27684793 |
2016 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The 2184A/G polymorphism in the AGER gene is not associated with DR in Han Chinese patients with T2DM.
|
27033231 |
2016 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The gene coding for vascular endothelial growth factor, aldose reductase, and the receptor for advanced glycation end products have been extensively evaluated, and specific polymorphisms of these genes have been suggested to potentially increase the risk of DR development.
|
24138043 |
2014 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Association of the receptor for advanced glycation end products gene polymorphisms and circulating RAGE levels with diabetic retinopathy in the Chinese population.
|
24303504 |
2013 |
|
Diabetic Retinopathy
|
0.300 |
Biomarker
|
disease |
RGD |
Retinal upregulation of inflammatory and proangiogenic markers in a model of neonatal diabetic rats fed on a high-fat-diet.
|
23587252 |
2013 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The RAGE gene polymorphism 2245G/A is associated with pro-inflammatory, oxidative-glycation markers and circulating sRAGE in DR patients.
|
23545311 |
2013 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Otherwise, the RAGE Gly82Ser polymorphism might be considered a significant risk for DR in Asian populations.
|
22354095 |
2012 |
|
Diabetic Retinopathy
|
0.300 |
Therapeutic
|
disease |
RGD |
Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats.
|
23146804 |
2012 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This is the first study that shows an association between the 2245A allele of the RAGE gene and development of diabetic retinopathy in the Malaysian population.
|
22116960 |
2012 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Association analysis of -429T/C and -374T/A polymorphisms of receptor of advanced glycation end products (RAGE) gene in Malaysian with type 2 diabetic retinopathy.
|
22154374 |
2012 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggested that there might be no association of RAGE gene polymorphisms (Gly82Ser, 1704G/T, 429T/C) with T2DM, DR and DN risk.
|
22475522 |
2012 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Z+2 allele of ALR2, 13-repeat genotype of iNOS, 15-repeat genotype of TNF-β, genes were associated with susceptibility to DR. Gly82Ser polymorphisms of the RAGE gene were not associated with DR in the present study.
|
21067489 |
2010 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Among the nine loci (15 polymorphisms) screened, SNP rs2070600 (rs2070600" genes_norm="177;3077;5891">G82S) in the RAGE gene, showed significant association with DR (allelic P = 0.016, dominant model P = 0.012), compared to DNR.
|
21067572 |
2010 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
G82S polymorphism in the RAGE gene is associated with DR and G-A haplotype containing 1704G and 82S allele might be a genetic marker of DR in Chinese T2DM patients.
|
19542745 |
2009 |
|
Diabetic Retinopathy
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Olmesartan blocks advanced glycation end products (AGEs)-induced angiogenesis in vitro by suppressing receptor for AGEs (RAGE) expression.
|
17560613 |
2008 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Rage gene promoter polymorphisms and diabetic retinopathy in a clinic-based population from South India.
|
16440015 |
2007 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Rage gene promoter polymorphisms and diabetic retinopathy in a clinic-based population from South India.
|
16440015 |
2007 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This study aims to investigate the frequency of Gly82Ser polymorphism in exon 3 of the receptor for AGE (RAGE) gene and its association with DR in Asian Indian patients who have type II diabetes.
|
12477623 |
2003 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Our study failed to demonstrate an association between either - 429 T/C or - 374 T/A gene polymorphism of the RAGE gene and diabetic retinopathy in Caucasians with type 2 diabetes.
|
14704946 |
2003 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
-429T/C and -374T/A polymorphisms of RAGE gene promoter are not associated with diabetic retinopathy in Chinese patients with type 2 diabetes.
|
12941744 |
2003 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
This study aims to investigate the frequency of Gly82Ser polymorphism in exon 3 of the receptor for AGE (RAGE) gene and its association with DR in Asian Indian patients who have type II diabetes.
|
12477623 |
2003 |
|
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Effects of novel polymorphisms in the RAGE gene on transcriptional regulation and their association with diabetic retinopathy.
|
11375354 |
2001 |