|
Idiopathic osteoarthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The association between DNA methyltransferases (DNMTs) genes polymorphisms and diseases in which DNA methylation plays a role in their pathogenesis has been described (e.g., cancer); however, its relationship with OA has not been investigated.
|
31713648 |
2020 |
|
Generalized osteoarthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The association between DNA methyltransferases (DNMTs) genes polymorphisms and diseases in which DNA methylation plays a role in their pathogenesis has been described (e.g., cancer); however, its relationship with OA has not been investigated.
|
31713648 |
2020 |
|
Myeloid neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
We thus identified minimum doses of decitabine (0·1-0·2 mg/kg) that deplete DNMT1 without off-target anti-metabolite effects/cytotoxicity, and then administered these well-tolerated doses frequently 1-2X/week to increase S-phase dependent DNMT1-depletion, and used a Myeloid Malignancy Registry to evaluate long-term outcomes in 69 patients treated this way.
|
31736067 |
2020 |
|
Malignant neoplasm of endometrium
|
0.010 |
Biomarker
|
disease |
BEFREE |
In endometrial cancer DNMT1 presented a potential role in enhancing cancer cell metastasis by inducing epithelial-mesenchymal transition (EMT).
|
30146796 |
2019 |
|
Febrile Convulsions
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Together, the findings of this descriptive cross-sectional pilot study demonstrated brain region-specific changes in DNMT1 and DNMT3a isoform expression as well as global DNA methylation levels in human TLE with or without a history of FS.
|
31426844 |
2019 |
|
Dyskinetic syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found that LBPM developed less AIM severity compared with standard L-dopa administration, whereas selective deletion of β-arrestin2 in striatum neurons dramatically enhanced the severity of dyskinesia by LBPM.
|
31275144 |
2019 |
|
Membranous glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Predicting risk of pulmonary infection in patients with primary membranous nephropathy on immunosuppressive therapy: The AIM-7C score.
|
30499223 |
2019 |
|
Heartburn
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
For simulated data, there is good agreement between ISORROPIA II and E-AIM IV predicted acidity in the forward and metastable mode, resulting from the hydrogen ion activity coefficient (γ<sub>(H<sup>+</sup>)</sub>) and the molality (<i>m</i><sub>(H<sup>+</sup>)</sub>) showing opposite trends.
|
31294542 |
2019 |
|
Hirschsprung Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
This work shows that genes controlling epigenetic modifications are important to coordinate intestinal tract development, provides the first demonstration that these genes influence development of the ENS, and advances uhrf1 and dnmt1 as potential new Hirschsprung disease candidates.
|
31394080 |
2019 |
|
Hypothyroidism
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Curcumin restores hepatic epigenetic changes in propylthiouracil(PTU)Induced hypothyroid male rats: A study on DNMTs, MBDs, GADD45a, C/EBP-β and PCNA.
|
30367912 |
2019 |
|
Lymphoma, Non-Hodgkin
|
0.010 |
Biomarker
|
disease |
BEFREE |
Downregulation of miR-152 contributes to DNMT1-mediated silencing of SOCS3/SHP-1 in non-Hodgkin lymphoma.
|
30470842 |
2019 |
|
Malaria
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on in vitro activity against drug susceptible and drug-resistant P. falciparum lines, selectivity index criterion and favorable pharmacokinetic properties, four compounds, one HDAC inhibitor (1) and three DNMT inhibitors (37, 43 and 45), were selected for preclinical studies in a mouse model of malaria.
|
30366254 |
2019 |
|
Chloasma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The relative expression of DNMT1 was significantly elevated in melasma compared with unaffected skin in all subjects, indicating DNA hypermethylation.
|
31143777 |
2019 |
|
Myocardial Infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we demonstrated that α-SMA was overexpressed and DNMT1 expression was downregulated in the infarct area after myocardial infarction.
|
30362530 |
2019 |
|
Rheumatism
|
0.010 |
Biomarker
|
disease |
BEFREE |
We considered women with autoimmune rheumatic diseases as an exemplar group of long term illnesses, to explore the barriers and enablers to breastfeeding AIM: To understand the experiences of infant feeding among women with autoimmune rheumatic diseases and to identify potential barriers and enablers.
|
31404778 |
2019 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
DNMT1 positivity was associated with shorter overall survival in bone metastasis (P = 0.017) and lung metastasis (P = 0.028) by univariate analysis.
|
28253728 |
2019 |
|
Right Ventricular Hypertrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Histological changes (right ventricular hypertrophy index, medial wall thickness in pulmonary arteries (PAs)) and DNMT1 protein levels in rat PAs or primary human PA smooth muscle cells (HPASMCs) exposed to cigarette smoke extract were assessed.
|
30845941 |
2019 |
|
Adult Non-Hodgkin Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Downregulation of miR-152 contributes to DNMT1-mediated silencing of SOCS3/SHP-1 in non-Hodgkin lymphoma.
|
30470842 |
2019 |
|
Childhood Non-Hodgkin Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Downregulation of miR-152 contributes to DNMT1-mediated silencing of SOCS3/SHP-1 in non-Hodgkin lymphoma.
|
30470842 |
2019 |
|
Metastatic malignant neoplasm to brain
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tumoral and stromal 5-meC showed the lowest expression in the bone metastasis (P < 0.001), tumoral DNMT1 showed the least expression in bone metastasis and the highest expression in the brain metastasis (P < 0.001).
|
28253728 |
2019 |
|
Abnormal behavior
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The brains of PRS mice, which are similar to the brains of patients with SZ and BP disorder, show an ∼2-fold increased binding of DNMT1 to psychiatric candidate promoters (glutamic acid decarboxylase 67, Reelin, and brain-derived neurotrophic factor), leading to their hypermethylation, reduced expression, as well as the behavioral endophenotypes reminiscent of those observed in the above psychiatric disorders.
|
30397000 |
2019 |
|
Enthesopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
AIM: Because of the wide diversity of developmental stages in spondyloarthropathies (SpA), clinical and radiographic weak correlations are often found in the development of enthesopathies.
|
30511294 |
2019 |
|
Autonomic neuropathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The fact that heterozygous mutations in DNMT1 are associated with hereditary sensory autonomic neuropathy provides plausibility to the present finding.
|
30548403 |
2019 |
|
Impaired cognition
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
No significant association was observed between DNMT1 rs2162560 and objective cognitive impairment.
|
31601979 |
2019 |
|
Neuropathy
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We assessed the frequency of five single-nucleotide polymorphisms in the gene encoding deoxyribonucleic acid methytransferase 1 (DNMT1; rs8112895, rs7254567, rs11085721, rs17291414 and rs10854076), and their associations with diabetic kidney disease, retinopathy, distal polyneuropathy and autonomic cardiovascular neuropathy in 359 individuals with long-term type 1 diabetes.
|
30548403 |
2019 |