DNMT1, DNA methyltransferase 1, 1786

N. diseases: 496; N. variants: 36
Disease: Adult Medulloblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278876
Disease: Adult Medulloblastoma
Adult Medulloblastoma 		0.340 Biomarker disease BEFREE Within this review, we summarize the main preclinical studies regarding epigenetic targets (such as HDAC, SIRT, BET, EZH2, G9a, LSD1, and DNMT) inhibitors in medulloblastoma. 30560106 2018
CUI: C0278876
Disease: Adult Medulloblastoma
Adult Medulloblastoma 		0.340 AlteredExpression disease BEFREE Increased cytomegalovirus replication by 5-Azacytidine and viral-induced cytoplasmic expression of DNMT‑1 in medulloblastoma and endothelial cells. 29484388 2018
CUI: C0278876
Disease: Adult Medulloblastoma
Adult Medulloblastoma 		0.340 Biomarker disease BEFREE We found that in HDAC1 and DNMT1 overexpressing medulloblastoma-derived cells, cell death was induced under various epigenetic drug conditions tested. 28429280 2017
CUI: C0278876
Disease: Adult Medulloblastoma
Adult Medulloblastoma 		0.340 AlteredExpression disease BEFREE In conclusion, DNMT1, DNMT3A and DNMT3B are highly expressed in human medulloblastoma samples, suggesting that promoter hypermethylation may play a role in medulloblastoma development. 27543768 2016
CUI: C0278876
Disease: Adult Medulloblastoma
Adult Medulloblastoma 		0.340 Biomarker disease CTD_human Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice. 19155313 2009