Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The combination of NPM1, DNMT3A, and IDH1/2 mutations leads to inferior overall survival in AML.
|
31145495 |
2019 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Somatic DNMT3A mutations at R882 are frequently observed in AML patients including the very abundant R882H, but also R882C, R882P and R882S.
|
31620784 |
2019 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we develop independently regulatable mutations in DNA methyltransferase 3A (Dnmt3a) and nucleophosmin 1 (Npm1), observed in human CH and AML, respectively.
|
30692594 |
2019 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition, DNMT3A R882 mutations were associated with an inferior response to induction therapy with aclarubicin in Chinese AML patients.
|
31291961 |
2019 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A 22-year-old male was diagnosed with acute monocytic leukemia with FLT3-ITD and DNMT3A mutations and pulmonary infection.
|
29843647 |
2018 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The DNA methyltransferase DNMT3A R882H mutation is observed in 25% of all AML patients.
|
30185810 |
2018 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis.
|
28061354 |
2017 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We detected the mutations in DNMT3A exon 23 by polymerase chain reaction and direct sequencing in 342 children with AML (0-16 years old) from January 2005 to June 2013, treated on BCH-2003 AML protocol.
|
28767575 |
2017 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
|
28215704 |
2017 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In summary, the present cohort study demonstrated that FLT3-ITD and DNMT3A R882 double mutation predicts poor prognosis in Chinese AML patients receiving chemotherapy or allo-HSCT treatment.
|
28616699 |
2017 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of DNMT3A genetic polymorphisms as outcome predictors in AML patients.
|
27528035 |
2016 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
DNMT3A R882 Mutations Predict a Poor Prognosis in AML: A Meta-Analysis From 4474 Patients.
|
27149454 |
2016 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In multivariate analyses including a comprehensive set of molecular and clinical variables, we identified DNMT3A and RUNX1 mutations as important predictors of shorter overall survival (OS) in AML patients <60 years, and particularly in those with intermediate-risk cytogenetics.
|
27288520 |
2016 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
DNMT3A mutations are associated with FLT3 ITD mutations but do not affect clinical outcome significantly in Korean NK AML patients.
|
25650308 |
2015 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Persistence of DNMT3A mutations at long-term remission in adult patients with AML.
|
25371149 |
2014 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We show that GATA2(low) AML lack the prototypical R882 mutation in DNMT3A frequently observed in NK-AML patients and that The Cancer Genome Atlas AML specimens with DNMT3A R882 mutations are characterized by CpG hypomethylation of GATA2.
|
24514424 |
2014 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.
|
24656771 |
2014 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
DNMT3A mutation is a poor prognosis biomarker in AML: results of a meta-analysis of 4500 AML patients.
|
23962568 |
2013 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG).
|
23632886 |
2013 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.
|
21399634 |
2011 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study shows that DNMT3A mutations have no impact on outcome but could be a predictive factor for response to idarubicin and thus, could have a direct influence in the way AML patients should be managed.
|
22081665 |
2011 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.
|
21399634 |
2011 |