Evaluation of sensitivity to 5-FU on the basis of thymidylate synthase (TS)/dihydropyrimidine dehydrogenase (DPD) activity and chromosomal analysis in micro tissue specimens of breast cancer.
Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis.
In vitro study demonstrated that capecitabine was effective against the BT-483 and MB-MDA-231 breast carcinoma cell lines used but the significance of the status of intratumoral TP and DPD in determining its therapeutic efficacy needs further studies.
The prognostic significance of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in breast carcinomas.
DPD (dihydropyrimidine dehydrogenase, encoded by <i>DPYD</i> gene) is the initial and rate-limiting enzyme of metabolic pathway of fluoropyrimidines, and fluoropyrimidines are common used drug therapies for breast cancer.