DPYSL2, dihydropyrimidinase like 2, 1808

N. diseases: 93; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.310 GeneticVariation disease UNIPROT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.400 AlteredExpression disease BEFREE We used proteomics to detect differences in protein expression between control, DS and Alzheimer's disease brains: In five individual brain regions of 9 individuals of each group we performed two dimensional electrophoresis with MALDI--identification of proteins and determined mRNA levels of DRP-2. 10666674 1999
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.020 AlteredExpression disease BEFREE The decrease of mRNA DRP-2 steady state levels in DS along with deteriorated protein expression of this repulsive guidance molecule of the semaphorin/collapsin family, may help to explain deranged migration and histogenesis of DS brain and wiring of AD brain. 10666674 1999
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome 		0.010 AlteredExpression disease BEFREE The decrease of mRNA DRP-2 steady state levels in DS along with deteriorated protein expression of this repulsive guidance molecule of the semaphorin/collapsin family, may help to explain deranged migration and histogenesis of DS brain and wiring of AD brain. 10666674 1999
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.400 Biomarker disease BEFREE The phosphorylation of this particular portion carboxyl-terminal to the basic region of CRMP-2 may play an important role in regulating its activity, and may be involved in the formation of degenerating neurites in AD brain. 10757975 2000
CUI: C0020676
Disease: Hypothyroidism
Hypothyroidism 		0.200 Biomarker disease RGD Significant higher CRMP-2 protein but not CRMP-4 protein was found in the hypothyroid rats. 11694350 2001
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.020 AlteredExpression disease LHGDN Evaluation of DRP-2, DRP-3 and DRP-4 revealed significantly decreased levels of 2 of the 15 spots assigned to DRP-2 and increased levels of one spot assigned to DRP-3 and increased DRP-4 in DS brain. 11771764 2001
CUI: C0036349
Disease: Paranoid Schizophrenia
Paranoid Schizophrenia 		0.320 Biomarker disease BEFREE The human dihydropyrimidinase-related protein 2 gene on chromosome 8p21 is associated with paranoid-type schizophrenia. 12679234 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation disease BEFREE Our results suggest that the *2236C allele in the 3'UTR of the DRP-2 gene, or an unknown mutation in linkage disequilibrium with this allele, may reduce the susceptibility to schizophrenia, especially the paranoid subtype. 12679234 2003
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease PSYGENET No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans. 12951196 2003
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease BEFREE No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans. 12951196 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation disease BEFREE Recently, we demonstrated a significant association between the DRP-2 gene and schizophrenia. 12951196 2003
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.020 Biomarker disease BEFREE The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD. 12951196 2003
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia 		0.020 Biomarker disease BEFREE The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD. 12951196 2003
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.040 AlteredExpression disease BEFREE Here we show that glial cell line-derived neurotrophic factor (GDNF) enhances CRMP-2 expression in TGW human neuroblastoma cells via activation of RET receptor tyrosine kinase. 15207709 2004
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.040 AlteredExpression disease BEFREE Here we show that glial cell line-derived neurotrophic factor (GDNF) enhances CRMP-2 expression in TGW human neuroblastoma cells via activation of RET receptor tyrosine kinase. 15207709 2004
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.040 AlteredExpression disease BEFREE Here we show that glial cell line-derived neurotrophic factor (GDNF) enhances CRMP-2 expression in TGW human neuroblastoma cells via activation of RET receptor tyrosine kinase. 15207709 2004
CUI: C0014556
Disease: Epilepsy, Temporal Lobe
Epilepsy, Temporal Lobe 		0.010 Biomarker disease LHGDN Reduction of hippocampal collapsin response mediated protein-2 in patients with mesial temporal lobe epilepsy. 15672539 2004
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.400 Biomarker disease BEFREE The dual-phosphorylated CRMP2, but not non-phosphorylated or single-phosphorylated CRMP2, is recognized with the antibody 3F4, which is highly reactive with the neurofibrillary tangles of Alzheimer's disease. 15676027 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation disease LHGDN We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia. 15858820 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation disease BEFREE We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia. 15858820 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 Biomarker disease BEFREE Case-control and TDT analyses were performed to detect association of DPYSL2 with schizophrenia. 16321170 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease PSYGENET We have previously demonstrated that the DRP-2 gene is associated with susceptibility to schizophrenia, but not to bipolar disorders. 17105906 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 GeneticVariation disease BEFREE We have previously demonstrated that the DRP-2 gene is associated with susceptibility to schizophrenia, but not to bipolar disorders. 17105906 2006
CUI: C0036349
Disease: Paranoid Schizophrenia
Paranoid Schizophrenia 		0.320 GeneticVariation disease BEFREE The polymorphism *2236T>C in the 3' untranslated region of the DRP-2 gene, which has been shown to be a negative genetic risk factor for paranoid-type schizophrenia, was analyzed in 198 patients with METH psychosis and 221 corresponding healthy controls in a Japanese population. 17105906 2006