DRD1, dopamine receptor D1, 1812

N. diseases: 181; N. variants: 8
Disease: Bipolar Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 Biomarker disease PSYGENET A genetic association exists between DRD1 gene and impaired cognition in BD. 25233244 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 Biomarker disease BEFREE A genetic association exists between DRD1 gene and impaired cognition in BD. 25233244 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 AlteredExpression disease BEFREE Patients with affective disorders showed an opposite pattern: reduced expression of D2S (major depressive disorder, P<0.0001) and increased expression of D2L and DRD1 (bipolar disorder, P<0.0001). 24322206 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 Biomarker disease PSYGENET Patients with affective disorders showed an opposite pattern: reduced expression of D2S (major depressive disorder, P<0.0001) and increased expression of D2L and DRD1 (bipolar disorder, P<0.0001). 24322206 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 AlteredExpression disease BEFREE Vitamin D receptor FokI genotype may modify the susceptibility to schizophrenia and bipolar mood disorder by regulation of dopamine D1 receptor gene expression. 23042374 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 Biomarker disease PSYGENET Vitamin D receptor FokI genotype may modify the susceptibility to schizophrenia and bipolar mood disorder by regulation of dopamine D1 receptor gene expression. 23042374 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 Biomarker disease PSYGENET Here we compare gene expression levels for 17 genes [including all 11 dopamine receptor interacting proteins, all 5 dopamine receptors (DRD1-DRD5) and DARPP-32] by real-time polymerase chain reaction, using prefrontal cortex post mortem brain samples from 33 schizophrenic, 32 bipolar disorder and 34 control subjects. 20874815 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 Biomarker disease PSYGENET Polymorphisms within the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes are being studied for association with lithium prophylaxis in a sample of 155 Sardinian unrelated probands affected by bipolar disorder (BP). 19647327 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 Biomarker disease CTD_human Dopamine D1 receptor gene polymorphism is associated with prophylactic lithium response in bipolar disorder. 19153942 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 GeneticVariation disease BEFREE Genetic association between three DRD1 single nucleotide polymorphisms (SNPs) (-800T/C, -48A/G, and 1403T/C) and bipolar type I (BP I) disorder was performed in a case-control sample of Sardinian origin (170 BP I and 209 controls) and in an enlarged sample (229 families) of BP I trios from Toronto. 17066478 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 GeneticVariation disease LHGDN These data suggest that the -48A/G polymorphism of the DRD1 gene may be involved in the etiology of bipolar disorder in a Polish population. 16397404 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 GeneticVariation disease BEFREE These data suggest that the -48A/G polymorphism of the DRD1 gene may be involved in the etiology of bipolar disorder in a Polish population. 16397404 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 Biomarker disease BEFREE In line with a considerable amount of evidence, the dopamine D1 receptor gene (DRD1) is considered to be a good candidate gene for bipolar disorders. 15704231 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 Biomarker disease BEFREE There is also growing evidence for the role of DRD1, NMDA receptor genes (GRIN1, GRIN2A, GRIN2B), brain-derived neurotrophic factor (BDNF), and dopamine transporter (SLC6A3) in both schizophrenia and bipolar disorder. 15952869 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 Biomarker disease BEFREE Based on the dopamine hypothesis, the dopamine D1 receptor gene (DRD1) is considered to be a good candidate gene for bipolar disorder (BP). 12488059 2002
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 GeneticVariation disease BEFREE Allele frequencies were similar in patients and controls, indicating that genetic variation in the 5'-regulatory region of the DRD1 gene is unlikely to play a frequent, major role in the genetic predisposition to either schizophrenia or bipolar affective disorder. 8837716 1996
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.600 Biomarker disease BEFREE Linkage of bipolar disorder and recurrent depression to DRD1 and DRD2 was tested using a series of genetic models with varying penetrance levels. 1385598 1992