|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the genetic predisposition to schizophrenia in these pedigrees is not due to aberrations in the DRD2 locus or the porphobilinogen deaminase locus.
|
2069495 |
1991 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent reports of cytogenetic abnormalities linked to psychiatric illness and the localisations of the genes for the dopamine (D2) receptor and tyrosinase on the long arm of chromosome 11 have suggested that susceptibility loci for schizophrenia and manic depression might be situated in this region.
|
1677600 |
1991 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
No structural changes were found, suggesting that alteration in the structure of the dopamine D2 receptor is not commonly involved in the etiology of schizophrenia.
|
1837284 |
1991 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The dopamine D2 receptor gene is a candidate gene for schizophrenia.
|
1475034 |
1992 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Schizophrenia: normal sequence in the dopamine D2 receptor region that couples to G-proteins. DNA polymorphisms in D2.
|
8471125 |
1993 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the major component of genetic susceptibility to schizophrenia is not due to allelic variation at the DRD2 locus or other genes in the surrounding chromosomal region.
|
8439241 |
1993 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No evidence of linkage between the dopamine D2 receptor gene and schizophrenia.
|
7824680 |
1994 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of dopamine D2 receptor molecular variant with schizophrenia.
|
7907680 |
1994 |
|
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The possibility that schizophrenia is associated with a differential expression, in the brain, of the short and long isoforms of the dopamine D2 receptor has been investigated by assessing the abundance of mRNA for each of the isoforms.
|
7984046 |
1994 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No major role for the dopamine D2 receptor Ser-->Cys311 mutation in schizophrenia.
|
7712120 |
1994 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mismatch PCR RFLP detection of DRD2 Ser311Cys polymorphism and schizophrenia.
|
7914079 |
1994 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No structural coding abnormalities in the DRD2 gene are present in alcoholism or schizophrenia.
|
8277546 |
1994 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Exclusion of linkage of schizophrenia to the gene for the dopamine D2 receptor (DRD2) and chromosome 11q translocation sites.
|
7480434 |
1995 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The 11q21-22 region, including DRD2, was surveyed by linkage analysis in a sample (N = 242) made of four large multigenerational pedigrees densely affected by schizophrenia (SZ) and eight others by bipolar disorder (BP).
|
8825888 |
1995 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results do not support the argument that the Cys311 allele of DRD2 poses a genetic risk for certain types of schizophrenia in Chinese populations.
|
8837714 |
1996 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results are compatible with the view that the tyrosine hydroxylase, dopamine receptor D2 and D4 gene polymorphisms examined are not of major importance in the aetiology or pathophysiology of schizophrenia.
|
8908411 |
1996 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
[1994] indicated that an association between the dopamine D2 receptor gene and schizophrenia is unlikely to exist.
|
8723049 |
1996 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A mutation in the DRD2 receptor gene has been reported in association with schizophrenia in Japanese and Caucasian populations.
|
8886166 |
1996 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Further association study on dopamine D2 receptor variant S311C in schizophrenia and affective disorders.
|
8723039 |
1996 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated a variant of the dopamine D2 receptor gene (Ser311/Cys311 substitution) in Caucasian patients with schizophrenia (n = 273), delusional disorder (n = 62), bipolar I affective disorder (n = 63), and controls (n = 255).
|
8837713 |
1996 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our purpose was to test the dopamine D2 receptor gene (DRD2), the tyrosine hydroxylase (TH) gene and the monoamino oxydase A (MAO-A) gene for linkage to schizophrenia and bipolar disorders.
|
8710185 |
1996 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings show that the -141C Ins/Del may be a functional polymorphism in the 5'-promoter region of DRD2 and may affect the susceptibility to schizophrenia.
|
9097961 |
1997 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Linkage and association of a functional DRD2 variant [Ser311Cys] and DRD2 markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians.
|
9259374 |
1997 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An association study between the Cys311 variant of dopamine D2 receptor gene and schizophrenia in the Okinawan population.
|
9472122 |
1997 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No association of the Ser/Cys311 DRD2 molecular variant with schizophrenia using a classical case control study and the haplotype relative risk.
|
9187010 |
1997 |